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Tropicamide information from DrugsUpdate  

See Available Brands of Tropicamide in India

P - Caution when used during pregnancy

Tropicamide (Mydriacyl) is an anticholinergic used as a mydriatic.

Pharmacodynamics

Pharmacokinetics

Tropicamide is a tertiary amine antimuscarinic which causes relaxation of the sphincter muscle of the iris resulting in pupillary dilatation. It also causes paralysis of the ciliary muscle leading to loss of accommodation.

Onset

Mydriasis: 20-40 minutes; cycloplegia: 30 minutes.

Duration
Mydriasis: 6 hours; cycloplegia: 6 hours.

Tropicamide Indications / Tropicamide Uses

Information Not Available

Tropicamide Adverse Reactions / Tropicamide Side Effects

Increased intraocular pressure, transient stinging, dry mouth, blurred vision, photophobia, tachycardia, headache, superficial punctate keratitis, systemic anticholinergic effects, severe CNS disturbances in children (rare).

Precautions

In the elderly and others where increased intraocular pressure may be encountered, mydriatics and cycloplegics should be used cautiously. To avoid inducing angle closure glaucoma, an estimation of the depth of the angle of the anterior chamber should be made. The lacrimal sac should be compressed by digital pressure for two to three minutes after instillation to avoid excessive systemic absorption.

Special Precautions

Elderly, children, pregnancy. Hypertension, hyperthyroidism, DM, cardiac disorders. To reduce systemic absorption, press on the lacrimal sac for 1-2 minutes following instillation. Do not drive or engage in hazardous activities and protect eyes from bright illumination when pupils are dilated. May fail to produce adequate cycloplegia in children.

Other Drug Interactions

May antagonise effects of ophthalmic carbachol, pilocarpine, or cholinesterase inhibitors.

Other Interactions

Information Not Available

Dosage

Ophthalmic
Production of mydriasis
Adult: Instill 1-2 drops of a 0.5% solution 15-20 minutes before examination.

Ophthalmic

Production of cycloplegia
Adult: Instill 1-2 drops of a 1% solution repeated after 5 minutes. An additional drop may be admin after 20-30 minutes for prolonged effect.

Food(before/after)

Information Not Available

List of Contraindications

Tropicamide and Pregnancy

Caution when used during pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Tropicamide and Lactation

Information Not Available

Tropicamide and Children

Information Not Available

Tropicamide and Geriatic

Information Not Available

Tropicamide and Other Contraindications

Hypersensitivity. Narrow-angle glaucoma or shallow anterior chamber.

Storage

Ophthalmic
Store between 15-30°C. Do not refrigerate

Lab interference

Ophthalmic
Store between 15-30°C. Do not refrigerate

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