Trimetazidine is a cellular acting anti-ischaemic agent. It has 3 main properties by which it acts as a cytoprotective agent. It inhibits the anaerobic glycolysis and fatty acid metabolism, thus allowing only aerobic glycolysis. This action helps to restore the energy balance in the cell. It inhibits acidosis and free radical accumulation in the cell. All these action help the cell to restore the normal ionic and metabolic balance.

Absorption
Rapidly absorbed. Peak plasma concentration: within 2 hours (conventional tab); 5 hours (modified release).

Excretion
Via urine, mainly as unchanged drug. Half life: 6 hours (conventional); 7 hours (modified release).

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GI disturbances, vomiting, nausea.

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Oral
Angina pectoris, Meniere's disease
Adult: As conventional tab: 40-60 mg daily in divided doses.

Should be taken with food

Contraindicated in pregnancy

Contraindicated in lactation

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Hypersensitivity. Pregnancy and lactation

Oral
Store below 30°C.

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