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Trimetazidine Hydrochloride information from DrugsUpdate  

See Available Brands of Trimetazidine Hydrochloride in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Information Not Available

Pharmacodynamics

Pharmacokinetics

Trimetazidine is a cellular acting anti-ischaemic agent. It has 3 main properties by which it acts as a cytoprotective agent. It inhibits the anaerobic glycolysis and fatty acid metabolism, thus allowing only aerobic glycolysis. This action helps to restore the energy balance in the cell. It inhibits acidosis and free radical accumulation in the cell. All these action help the cell to restore the normal ionic and metabolic balance.

Absorption
Rapidly absorbed. Peak plasma concentration: within 2 hours (conventional tab); 5 hours (modified release).

Excretion

Via urine, mainly as unchanged drug. Half life: 6 hours (conventional); 7 hours (modified release).

Trimetazidine Hydrochloride Indications / Trimetazidine Hydrochloride Uses

Information Not Available

Trimetazidine Hydrochloride Adverse Reactions / Trimetazidine Hydrochloride Side Effects

GI disturbances, vomiting, nausea.

Precautions

Information Not Available

Special Precautions

Information Not Available

Other Drug Interactions

Information Not Available

Other Interactions

Information Not Available

Dosage

Oral
Angina pectoris, Meniere's disease
Adult: As conventional tab: 40-60 mg daily in divided doses.

Food(before/after)

Should be taken with food

List of Contraindications

Trimetazidine Hydrochloride and Pregnancy

Contraindicated in pregnancy

Trimetazidine Hydrochloride and Lactation

Contraindicated in lactation

Trimetazidine Hydrochloride and Children

Information Not Available

Trimetazidine Hydrochloride and Geriatic

Information Not Available

Trimetazidine Hydrochloride and Other Contraindications

Hypersensitivity. Pregnancy and lactation

Storage

Oral
Store below 30°C.

Lab interference

Oral
Store below 30°C.

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