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Terconazole information from DrugsUpdate  

See Available Brands of Terconazole in India

P - Caution when used during pregnancy
L - Contraindicated in lactation

Terconazole is an anti-fungal medication, primarily used to treat vaginal fungal infections.

Pharmacodynamics

Pharmacokinetics

Terconazole disrupts ergosterol synthesis by binding to fungal cytochrome P450. It is active in vitro against Candida spp and other fungi. It has some antibacterial activity in vitro but not against usual vag flora eg, lactobacilli.

Absorption
Intravaginal: 5-16% absorbed

Metabolism
Hepatic metabolism

Excretion

Excreted in urine and faeces.

Terconazole Indications / Terconazole Uses

Information Not Available

Terconazole Adverse Reactions / Terconazole Side Effects

Vulvovaginal burning, vulvar itching, dysmenorrhoea, genital, body and abdominal pain. Flu-like syndrome with headache, fever, chills and hypotension with doses >80 mg.

Precautions

Discontinue use and do not retreat with Terconazole if sensitization, irritation, fever, chills, or flu-like symptoms are reported during use.

The base contained in the suppository formulation may interact with certain rubber or latex products, such as those used in vaginal contraceptive diaphragms, therefore concurrent use is not recommended.

Special Precautions

Discontinue if irritation or flu-like symptoms develop. May damage latex or rubber contraceptives. Patients <18 years. Pregnancy.

Other Drug Interactions

Information Not Available

Other Interactions

Information Not Available

Dosage

Vaginal
Vulvovaginal candidiasis
Adult: 40 mg (as 0.8% vag cream) or 80 mg (as pessary) at bedtime for 3 consecutive nights or 20 mg (as 0.4% cream) at bedtime for 7 consecutive nights.

Food(before/after)

Information Not Available

List of Contraindications

Terconazole and Pregnancy

Caution when used during pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Terconazole and Lactation

Contraindicated in lactation

Terconazole and Children

Safety and efficacy not established

Terconazole and Geriatic

Clinical studies of Terconazole vaginal suppositories did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients.

Terconazole and Other Contraindications

Hypersensitivity. Lactation

Storage

Vaginal
Store between 15-30°C

Lab interference

Vaginal
Store between 15-30°C

Terconazole brands in India:

Gyno-Terazol

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