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Famotidine information from DrugsUpdate  

See Available Brands of Famotidine in India

P - Caution when used during pregnancy
L - Contraindicated in lactation

Famotidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and it is commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD). It is commonly marketed by Johnson & Johnson/Merck under the trade names Pepcidine and Pepcid. Unlike cimetidine, the first H2 antagonist, famotidine has no effect on the cytochrome P450 enzyme system, and does not appear to interact with other drugs.[1]

Pharmacodynamics

Pharmacokinetics

Famotidine competitively blocks histamine H2-receptors thus reducing basal, nocturnal and stimulated gastric acid secretion. Pepsin secretion is reduced resulting in decreased peptic activity. It effectively heals duodenal and gastric ulcers and prevents recurrence.


Absorption Readily but incompletely absorbed from the GI tract; peak plasma concentrations after 1-3 hr (oral).


Distribution Enters the breast milk. Protein-binding: 15-20%.


Metabolism Hepatic (small proportion); converted to famotidine S-oxide. Excretion Urine (as unchanged) within 24 hr; 2.5-3.5 hr (elimination half-life).

Famotidine Indications / Famotidine Uses

Information Not Available

Famotidine Adverse Reactions / Famotidine Side Effects

Headache, dizziness, constipation, diarrhoea, nausea, rash, GI discomfort, fatigue, gynaecomastia, impotence.

Precautions

Hypersensitivity Rare cases of anaphylaxis have occurred. Renal Function CrCl less than 50 mL/min Longer intervals between doses or lower doses may be needed. Benzyl Alcohol Multidose injection contains benzyl alcohol. Gastric malignancy Symptomatic response to famotidine does not preclude gastric malignancy. Phenylketonurics OTC chewable Pepcid AC contains phenylalanine 1.4 mg per tablet.

Special Precautions

Impaired renal function, liver cirrhosis; pregnancy. Possibility of malignancy should be considered prior to initiating treatment as drug may mask symptoms and delay diagnosis. No safety and efficacy data is available for children <1 yr.

Other Drug Interactions

Reduced absorption of famotidine with antacids hence admin should be separated by 2 hr. Reduced absorption of ketoconazole and itraconazole. Avoid ethanol (may cause gastric mucosal irritation).

Other Interactions

Information Not Available

Dosage

Oral Benign gastric and duodenal ulceration Adult: 40 mg daily at bedtime for 4-8 wk or 20 mg bid. To prevent recurrence of duodenal ulceration: 20 mg at bedtime may be taken. CrCl (ml/min): <50 Dosage Recommendation: Halve the dose or increase dosing interval to 36-48 hr. Oral Gastro-oesophageal reflux disease Adult: 20 mg bid for 6-12 wk or up to 40 mg bid if there is oesophageal ulceration. Maintenance dose: 20 mg bid may be given to prevent recurrence. Child: 1-16 yr: 1-2 mg/kg/day divided bid up to 40 mg bid. CrCl (ml/min): <50 Dosage Recommendation: Halve the dose or increase dosing interval to 36-48 hr. Oral Zollinger-Ellison syndrome Adult: Initially, 20 mg every 6 hr, up to 800 mg daily if necessary. Child: 1-16 yr: 0.5-1 mg/kg/day up to 40 mg/day, given once at bedtime or taken bid. CrCl (ml/min):<50 Dosage Recommendation: Halve the dose or increase dosing interval to 36-48 hr. Oral Non-ulcer dyspepsia Adult: 10 mg bid. CrCl (ml/min):<50 Dosage Recommendation: Halve the dose or increase dosing interval to 36-48 hr. Oral Non-ulcer dyspepsia Adult: 10 mg bid. CrCl (ml/min):<50 Dosage Recommendation: Halve the dose or increase dosing interval to 36-48 hr. Oral Heartburn Adult: 10 mg bid. CrCl (ml/min):<50 Dosage Recommendation: Halve the dose or increase dosing interval to 36-48 hr. Intravenous Benign gastric and duodenal ulceration Adult: 20 mg every 12 hr, as an inj over at least 2 minutes or as an infusion over 15-30 minutes. CrCl (ml/min): <50 Dosage Recommendation: Halve the dose or increase dosing interval to 36-48 hr.

Food(before/after)

May be taken with or without food

List of Contraindications

Famotidine and Pregnancy

Caution when used during pregnancy Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Famotidine and Lactation

Contraindicated in lactation

Famotidine and Children

IV use in children younger than 1 yr of age not adequately studied. OTC only Consult health care provider for children younger than 12 years of age.

Famotidine and Geriatic

Information Not Available

Famotidine and Other Contraindications

Hypersensitivity; lactation

Storage

Intravenous Refrigerate at 2-8℃ .Do not freeze. Oral Store below 25℃

Lab interference

Intravenous Refrigerate at 2-8℃ .Do not freeze. Oral Store below 25℃

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