Drugsupdate.com is up for sale. To own one of the most recognized online brands by doctors in India with millions of visitors - click here.

logo image

Sisomicin information from DrugsUpdate  

See Available Brands of Sisomicin in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Sisomicin is an aminoglycoside antibiotic

Pharmacodynamics

Pharmacokinetics

Sisomicin binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.

Sisomicin Indications / Sisomicin Uses

Information Not Available

Sisomicin Adverse Reactions / Sisomicin Side Effects

Ototoxicity, nephrotoxicity, neurotoxicity (peripheral neuropathy, confusion, lethargy, hallucination, convulsion and mental depression, occasional respiratory depression), rarely hypersensitivity reaction.

Potentially Fatal: Acute renal failure especially in combination with other nephrotoxic drugs.

Precautions

Information Not Available

Special Precautions

Renal or liver impairment, myasthenia gravis, parkinsonism, dehydration, hypotension, pregnancy, lactation.

Other Drug Interactions

Plasma levels increased by indometacin. Antihistamines (H1-receptor blocker) may mask early signs of ototoxicity. Incompatible with some β-lactam antibiotics.

Potentially Fatal: Potentiates nephrotoxicity produced by other nephrotoxic drugs including other aminoglycosides, vancomycin and some cephalosporins. Potentiates ototoxicity produced by other aminoglycosides, ethacrynic acid. Ototoxicity potentiated by furosemide.

Other Interactions

Information Not Available

Dosage

Intramuscular
Susceptible Gram-negative and staphylococcal infections
Adult: 3 mg/kg daily in 2-3 divided doses. May also be given as IV infusion, if needed.
Renal impairment: May need to adjust maintenance doses and/or dosing intervals.

Topical/Cutaneous

Pyoderma
Adult: As 0.1% cream: Apply onto the affected area(s) bid.

Food(before/after)

Information Not Available

List of Contraindications

Sisomicin and Pregnancy

Caution when used during pregnancy

Sisomicin and Lactation

Caution when used during lactation

Sisomicin and Children

Information Not Available

Sisomicin and Geriatic

Information Not Available

Sisomicin and Other Contraindications

Hypersensitivity

Storage

Information Not Available

Lab interference

Information Not Available

© 2011-2019 DrugsUpdate.com. Disclaimer | Site Map

Feedback
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.