Silymarin information from DrugsUpdate
P - Contraindicated in pregnancy
L - Contraindicated in lactation
Silymarin, an antioxidant flavonoid complex derived from the herb milk thistle (Silybum marianum), has long been used as a liver tonic. Two new studies show that it can reduce insulin resistance (the underpinning of adult-onset diabetes, hypertension, and hypercholesterolemia) and diabetic complications. A third study reports that it may have some anti-cancer benefits as well.
Pharmacodynamics
Pharmacokinetics
Silymarin is an active principle from the fruit of Silybum marianum, which contains a mixture of flavonolignans. It reduces the turnover of membrane phospholipids and stabilises the cell membranes of hepatocytes. It has potent antioxidant action and prevents lipid peroxidation.
Silymarin Indications / Silymarin Uses
Information Not Available
Silymarin Adverse Reactions / Silymarin Side Effects
Occasional laxative effects. Abdominal bloating, diarrhoea, flatulence, loss of appetite, anorexia, nausea, stomach upset.
Precautions
Information Not Available
Special Precautions
Children
Other Drug Interactions
Information Not Available
Other Interactions
Information Not Available
Dosage
Oral
Hepatic diseases
Adult: 140 mg bid/tid.
Food(before/after)
Should be taken with food. (Take after meals.)
List of Contraindications
Silymarin and Pregnancy
Contraindicated in pregnancy
Silymarin and Lactation
Contraindicated in lactation
Silymarin and Children
Information Not Available
Silymarin and Geriatic
Information Not Available
Silymarin and Other Contraindications
Hypersensitivity, pregnancy, lactation
Storage
Information Not Available
Lab interference
Information Not Available
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