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Cinnarizine information from DrugsUpdate  

See Available Brands of Cinnarizine in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Cinnarizine is an anti-histaminic drug which is mainly used for the control of vomiting due to motion sickness. It is marketed under the brand Stugeron or Stunarone.

It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus. The disparity of signal processing between inner ear motion receptors and the visual senses is abolished, so that the confusion of brain whether the individual is moving or standing is reduced. Vomiting in motion sickness is actually a physiological compensatory mechanism of the brain to keep the individual from moving so that it can adjust to the signal perception.

Cinnarizine could be also viewed as a nootropic drug because of its vasorelaxating abilities (due to calcium channel blockage), which happen mostly in brain. It is also effectively combined with other nootropics, primarily piracetam; in such combination each drug potentiate the other in boosting brain oxygen supply.

Cinnarizine can be used in scuba divers without an increased risk of central nervous system oxygen toxicity.Cinnarizine can cause drowsiness and blurred vision. It is important that users make sure their reactions are normal before driving, operating machinery, or doing any other jobs which could be dangerous if they are not fully alert or able to see well.

Pharmacodynamics

Pharmacokinetics

Cinnarizine has calcium-channel blocking activity selective for arterial smooth muscle. It also has some antihistamine activity. Cinnarizine acts as a labyrinthine sedative. It also improves microcirculation by reducing ischaemia-induced blood viscosity.


Absorption
Absorbed from the GIT (oral); peak plasma concentrations after 2-4 hours.

Excretion
Via faeces (as unchanged drug), via urine (as metabolites); 3-6 hours (elimination half-life).

Cinnarizine Indications / Cinnarizine Uses

Information Not Available

Cinnarizine Adverse Reactions / Cinnarizine Side Effects

Extrapyramidal symptoms sometimes associated with severe depression. Drowsiness, headache, GI upsets, unsteadiness, headache; rarely skin and hypersensitivity reactions, dry mouth, blurred vision, urinary difficulty or retention, constipation and increased gastric reflux, fatigue. Hypolipidaemic effect.

Precautions

Information Not Available

Special Precautions

Hypotension; pregnancy; lactation; elderly. May impair ability to drive or operate machineries

Other Drug Interactions

CNS depressant effect enhanced with alcohol. Action potentiated by domperidone

Other Interactions

Information Not Available

Dosage

Oral
Peripheral vascular disease
Adult: 75 mg bid or tid.

Oral
Motion sickness
Adult: 30 mg taken 2 hours before travel and 15 mg every 8 hours during the journey if necessary.
Child: 5-12 years: 1/2 of adult dose.

Oral
Cerebrovascular disorders
Adult: 75 mg 1-3 times daily.

Oral
Vertigo and vestibular disorders.
Adult: 30 mg tid.
Child: 5-12 years: 1/2 of adult dose.

Food(before/after)

Should be taken with food

List of Contraindications

Cinnarizine and Pregnancy

Caution when used during pregnancy.


Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Cinnarizine and Lactation

Caution when used during lactation

Cinnarizine and Children

Information Not Available

Cinnarizine and Geriatic

Information Not Available

Cinnarizine and Other Contraindications

Proven hypersensitivity to the drug. Parkinson's disease. Children and neonates

Storage

Information Not Available

Lab interference

Information Not Available

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