logo image

Rizatriptan information from DrugsUpdate  

See Available Brands of Rizatriptan in India

P - Caution when used during pregnancy
L - Caution when used during lactation
FI - Food *

Rizatriptan (Maxalt) is a 5-HT1 agonist triptan drug developed by Merck & Co. for the treatment of migraine headaches. It is available in strengths of 5 and 10 mg as tablets and orally disintegrating tablets (Maxalt-MLT).

Pharmacodynamics

Pharmacokinetics

Rizatriptan is a selective serotonin (5-HT1) agonist in cranial arteries responsible for vasoconstriction and reduction of inflammation associated with antidromic neuronal transmission.

Absorption
Bioavailability: about 40-45%.

Distribution

Protein binding: 14%.

Metabolism
Primarily by monoamine oxidase type A.

Excretion

About 14% of an oral dose is excreted unchanged in the urine. Plasma half-life: about 2-3 hours.

Rizatriptan Indications / Rizatriptan Uses

Information Not Available

Rizatriptan Adverse Reactions / Rizatriptan Side Effects

Increased BP, chest pain, palpitation; skin flushing; dyspnoea; nausea, abdominal pain, dry mouth; dizziness, drowsiness, fatigue.

Potentially Fatal: Toxic epidermal necrolysis.

Precautions

Information Not Available

Special Precautions

Elderly; mild to moderate hepatic or renal impairment; coronary artery disease; pregnancy, lactation. May cause drowsiness. History of seizures. Ensure an interval of at least 24 hours after stopping an ergotamine compound and starting a serotonin (5-HT1) agonist.

Other Drug Interactions

Increased serum concentrations with propranolol. Increased risk of vasospastic reactions when used with ergotamine and methysergide. Concurrent use with SSRIs may increase risk of serotonin syndrome.

Potentially Fatal: Concurrent use with or within 2 wk of stopping MAOI treatment.

Other Interactions

Food Interaction
Absorption delayed. Concurrent use with St John's wort may increase risk of adverse reactions.

Dosage

Oral
Acute migraine attacks
Adult: Initially, 10 mg. If ineffective, 2nd dose should not be taken for the same attack. If symptoms recur after initial response, a further dose of 10 mg may be given. Doses should be separated by at least 2 hours. Max: 20 mg/24 hours. If patient is also taking propanolol, initiate with 5 mg. Max: 10 mg/24 hours. Ensure that the 2 drugs are separated by at least 2 hours.

Renal impairment: For mild-moderate impairment, initate with 5 mg. Further dose of 5 mg may be taken after an interval of at least 2 hours. Max: 10 mg/24 hours. Avoid in severe impairment.
Hepatic impairment: For mild-moderate impairment, initate with 5 mg. Further dose of 5 mg may be taken after an interval of at least 2 hours. Max: 10 mg/24 hours. Avoid in severe impairment.

Food(before/after)

May be taken with or without food.
Orally disintegrating tab: May be taken with or without food. (Place on the tongue & allow to dissolve; it can then be swallowed with the saliva.)

List of Contraindications

Rizatriptan and Pregnancy

Caution when used during pregnancy

Rizatriptan and Lactation

Caution when used during lactation

Rizatriptan and Children

Safety and efficacy not established

Rizatriptan and Geriatic

Information Not Available

Rizatriptan and Other Contraindications

History of MI, peripheral vascular disease, transient ishaemic attack, ischaemic heart disease or Prinzmetal's angina; uncontrolled hypertension; basilar or hemiplegic migraine; severe hepatic or renal impairment. Adolescent <18 years.

Storage

Oral
Store at 15-30°C

Lab interference

Oral
Store at 15-30°C

Rizatriptan brands in India:

Maxalt-RPD Migsun Ritza Rizact Rizatan

© 2011-2020 DrugsUpdate.com. Disclaimer | Site Map

Feedback
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.