Protionamide information from DrugsUpdate
L - Caution when used during lactation
Protionamide, a drug belongs to thiocarbamide group of derivatives, is prescribed for the systemic treatment of tuberculosis.
Protionamide is effective against mycobacterial species and exerts bacteriostatic action. Protionamide inhibits bacterial peptide synthesis and prevents microbial replication. Protionamide is effective against atypical mycobacteria such as M. avium, M. leprae, M. kansasii.
After oral administration, Protionamide the onset of drug action is within 30 to 60 minutes. The drug is readily absorbed in the GIT after oral administration. The Cmax can be achieved within two hours of administration. The drug is widely distributed in the body tissues and body fluids including CSF. Protionamide is metabolized and converted into active sulfoxide and other drug metabolites. Protionamide is mostly excreted via the urine as unchanged drug.
Protionamide can cause gynecomastia, nausea or vomiting, diarrhoea, abdominal pain, jaundice-like reactions, hepatitis, skin rashes, stomatitis, psychotic reactions with depressive disorders, anorexia, sialorrhoea, postural hypotension and taste changes.
Protionamide is contraindicated in patients with psychiatric disorders including depressive disorders, porphyria, severe hepatic disorders, diabetes mellitus and an allergy to Protionamide.
Difficulty in managing DM. Monitor blood glucose, thyroid and visual function. Perform LFT before and during treatment with protionamide. Caution in patients with psychiatric illness or depression. Pregnancy and lactation.
Increased neurotoxic effects with cycloserine.
Potentially Fatal: Increased incidence of hepatotoxicity with rifampicin.
For tuberculosis (Adults):
As an oral, second-line drug, consider administration of 15-20 mg/kg as a single dose. The maximum dose of Protionamide should not exceed 1g/day.
For tuberculosis (Pediatrics):
As an oral, second-line drug, consider administration of 10-15 mg/kg as a single dose.
The maximum dose of Protionamide should not exceed 750 mg/day.
Protionamide can be taken before or after food intake
List of Contraindications
USFDA Pregnancy category of Protionamide is unknown. Caution should be exercised before prescribing Protionamide to pregnant women.
Nursing mothers should consult a physician before taking Protionamide
Protionamide should not be given to children unless prescribed by a pediatrician
Hypersensitivity. Severe hepatic disease, porphyria.