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Protionamide information from DrugsUpdate  

See Available Brands of Protionamide in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Protionamide, a drug belongs to thiocarbamide group of derivatives, is prescribed for the systemic treatment of tuberculosis.

Pharmacodynamics

Protionamide is effective against mycobacterial species and exerts bacteriostatic action. Protionamide inhibits bacterial peptide synthesis and prevents microbial replication. Protionamide is effective against atypical mycobacteria such as M. avium, M. leprae, M. kansasii.

Pharmacokinetics

After oral administration, Protionamide the onset of drug action is within 30 to 60 minutes. The drug is readily absorbed in the GIT after oral administration. The Cmax can be achieved within two hours of administration. The drug is widely distributed in the body tissues and body fluids including CSF. Protionamide is metabolized and converted into active sulfoxide and other drug metabolites. Protionamide is mostly excreted via the urine as unchanged drug. 

Protionamide Indications / Protionamide Uses

Information Not Available

Protionamide Adverse Reactions / Protionamide Side Effects

Protionamide can cause gynecomastia, nausea or vomiting, diarrhoea, abdominal pain, jaundice-like reactions, hepatitis, skin rashes, stomatitis, psychotic reactions with depressive disorders, anorexia, sialorrhoea, postural hypotension and taste changes.

Precautions

Protionamide is contraindicated in patients with psychiatric disorders including depressive disorders, porphyria, severe hepatic disorders, diabetes mellitus and an allergy to Protionamide.

Special Precautions

Difficulty in managing DM. Monitor blood glucose, thyroid and visual function. Perform LFT before and during treatment with protionamide. Caution in patients with psychiatric illness or depression. Pregnancy and lactation.

Other Drug Interactions

Increased neurotoxic effects with cycloserine.

Potentially Fatal: Increased incidence of hepatotoxicity with rifampicin.

Other Interactions

Information Not Available

Dosage

For tuberculosis (Adults):
As an oral, second-line drug, consider administration of 15-20 mg/kg as a single dose. The maximum dose of Protionamide should not exceed 1g/day.

For tuberculosis (Pediatrics):
As an oral, second-line drug, consider administration of 10-15 mg/kg as a single dose.
The maximum dose of Protionamide should not exceed 750 mg/day.

Food(before/after)

Protionamide can be taken before or after food intake

List of Contraindications

Protionamide and Pregnancy

USFDA Pregnancy category of Protionamide is unknown. Caution should be exercised before prescribing Protionamide to pregnant women.

Protionamide and Lactation

Nursing mothers should consult a physician before taking Protionamide

Protionamide and Children

Protionamide should not be given to children unless prescribed by a pediatrician

Protionamide and Geriatic

Information Not Available

Protionamide and Other Contraindications

Hypersensitivity. Severe hepatic disease, porphyria.

Storage

Information Not Available

Lab interference

Information Not Available

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