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Propofol information from DrugsUpdate  

See Available Brands of Propofol in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Propofol, marketed as Diprivan by AstraZeneca is a short-acting, intravenously administered hypnotic agent. Its uses include the induction and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation. Propofol is also commonly used in veterinary medicine. Propofol is approved for use in more than 50 countries, and generic versions are available.

Pharmacodynamics

Pharmacodynamic properties of Propofol are dependent upon the therapeutic blood Propofol concentrations.  Steady-state Propofol blood concentrations are generally proportional to infusion rates.  Undesirable side effects, such as cardiorespiratory depression, are likely to occur at higher blood concentrations which result from bolus dosing or rapid increases in infusion rates.

Pharmacokinetics

Propofol is a short-acting anaesthetic given for induction and maintenance of general anaesthesia.

Onset
30 seconds

Duration

3-10 minutes

Distribution

Extensively redistributed from brain to other tissues; crosses the placenta and enters breast milk. Protein-binding: 95%

Metabolism
Extensively hepatic; converted to water-soluble sulfate and glucuronide conjugates.

Excretion
Urine (as metabolites); faeces. Elimination half-life:40 minutes (initial); 4-7 hours (terminal).

Propofol Indications / Propofol Uses

Information Not Available

Propofol Adverse Reactions / Propofol Side Effects

Involuntary muscle movements; nausea, vomiting, headache, fever; pain, burning or stinging at inj site.

Potentially Fatal: Apnoea, bradycardia, hypotension, convulsions; anaphylaxis.

Precautions

Information Not Available

Special Precautions

Paediatrics, elderly, hypovolaemia, epilepsy, lipid disorders, patients with increased intracranial pressure. Avoid rapid bolus doses in high risk patients. Emulsion formulation of propofol 2% should only be used in children >3 years.

Other Drug Interactions

Reduce dose if given with nitrous oxide or halogenated anaesthetics. Increased sedative, anaesthetic and cardiorespiratory effects when used with other CNS depressants.

Other Interactions

Information Not Available

Dosage

Intravenous
Induction and maintenance of general anaesthesia
Adult: Induction: 40 mg by injection or infusion every 10 seconds. Usual dose: 1.5-2.5 mg/kg. Maintenance: 4-12 mg/kg/hours or intermittent bolus injection of 20-50 mg.
Child: >8 years: Induction dose of 2.5 mg/kg. Maintenance dose: 9-15 mg/kg/hr by IV infusion or intermittent bolus injection.
Elderly: Including neurosurgical and debilitated patients: Infuse at a rate of 20 mg every 10 seconds. Maintenance: 3-6 mg/kg/hours. Usual dose needed: 1-1.5 mg/kg.

Intravenous
Sedation
Adult: In diagnostic and surgical procedures: Initially, 6-9 mg/kg/hours by infusion given for 3-5 minutes or an alternative dose of 0.5-1 mg/kg by slow inj over 1-5 minutes. Maintenance: 1.5-4.5 mg/kg/hours infusion. Reduce maintenance dose by 20% for high-risk patients needing sedation. For ventilated patients: 0.3-4 mg/kg/hours by infusion. Monitor lipid concentrations if duration of sedation lasts >3 days.

Food(before/after)

Information Not Available

List of Contraindications

Propofol and Pregnancy

Contraindicated in pregnancy

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Propofol and Lactation

Contraindicated in lactation

Propofol and Children

Safety and efficacy not established for induction anesthesia in children younger than 3 years of age or maintenance anesthesia in children younger than 2 months of age.

Propofol and Geriatic

Information Not Available

Propofol and Other Contraindications

Electroconvulsive therapy, obstetrics. Sedation in children ≤16 yr. Pregnancy, lactation.

Storage

Information Not Available

Lab interference

Information Not Available

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