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Praziquantel information from DrugsUpdate  

See Available Brands of Praziquantel in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Praziquantel (Biltricide) is an anthelmintic effective against flatworms.
Praziquantel is not licensed for use in humans in the UK; it is, however, available as a veterinary anthelmintic, and is available for use in humans on a named-patient basis.

Pharmacodynamics

Pharmacokinetics

Praziquantel is an anthelmintic with a broad spectrum of activity against trematodes (flukes) and cestodes (tapeworms). It increases the cell permeability to Ca in schistosomes, causing strong contractions and paralysis of worm musculature leading to detachment of suckers from the blood vessel walls and to dislodgement.

Absorption
80% of dose is rapidly absorbed from the GIT (oral); peak plasma concentrations after 1-3 hours.

Distribution
CSF, enters breast milk.

Metabolism
Rapid and extensive hepatic first-pass metabolism by hydroxylation.

Excretion
Via urine (as metabolites); elimination half-life: 1-1.5 hours (parent drug), 4 hours (metabolites).

Praziquantel Indications / Praziquantel Uses

Information Not Available

Praziquantel Adverse Reactions / Praziquantel Side Effects

Headache, drowsiness, dizziness, malaise, abdominal discomfort, nausea, vomiting, diarrhoea, urticaria, rashes, pruritus, fever, eosinophilia.

Precautions

Information Not Available

Special Precautions

Driving or operating machinery during or for 24 hours after treatment. Severe hepatic disease. Do not breastfeed during or for 72 hours after treatment.

Other Drug Interactions

Reduced plasma concentrations when used with dexamethasone. Carbamazepine, phenytoin and chloroquine may reduce the bioavailability of praziquantel while cimetidine may increase the bioavailabilty of praziquantel.

Other Interactions

Information Not Available

Dosage

Oral
Schistosomiasis
Adult: 3 doses of 20 mg/kg every 4-6 hours or 40-60 mg/kg as a single dose.
Child: >4 years: Same as adult dose.

Oral
Clonorchiasis
Adult: 25 mg/kg tid for 1-2 days or 40 mg/kg as a single daily dose.
Child: >4 years: Same as adult dose.

Oral
Intestinal fluke infections
Adult: 25 mg/kg tid for 1-2 days or 40 mg/kg as a single daily dose.
Child: >4 years: Same as adult dose.

Oral
Lung fluke infections
Adult: 25 mg/kg tid for 1-2 days or 40 mg/kg as a single daily dose.
Child: >4 years: Same as adult dose.

Oral
Opisthorchiasis
Adult: 25 mg/kg tid for 1-2 days or 40 mg/kg as a single daily dose.
Child: >4 years: Same as adult dose.

Oral
Tapeworm infections
Adult: 5-25 mg/kg as a single dose.
Child: >4 years: Same as adult dose.

Oral
Neurocysticercosis
Adult: 50 mg/kg/day, given in 3 divided doses for 14 days. Alternatively, 3 doses of 25 mg/kg every 2 hours.

Food(before/after)

Should be taken with food. (Swallow whole, do not chew/crush )

List of Contraindications

Praziquantel and Pregnancy

Contraindicated in pregnancy

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Praziquantel and Lactation

Contraindicated in lactation

Praziquantel and Children

Safety and efficacy not established in children younger than 4 years of age.

Praziquantel and Geriatic

Information Not Available

Praziquantel and Other Contraindications

Hypersensitivity, ocular cysticercosis

Storage

Information Not Available

Lab interference

Information Not Available

Praziquantel brands in India:

Cest Cysticide Distocide Prazine

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