Deflazacort information from DrugsUpdate
L - Caution when used during lactation
FI - Food *
Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant. Deflazacort is a prodrug. Its potency is around 70?90% that of prednisone.
Deflazacort, derived from prednisolone, is a corticosteroid with mainly glucocorticoid activity. An anti-inflammatory dose of 6 mg deflazacort is equiv to 5 mg prednisolone.
GI disturbances, musculoskeletal, endocrine, neuropsychiatric, ophthalmic, fluid and electrolyte disturbances; susceptible to infection, impaired healing, hypersensitivity, skin atrophy, striae, telangiectasia, acne, myocardial rupture following recent MI, thromboembolism.
Adrenal suppression and infection, child, adolescents, elderly, history of TB and steroid myopathy, hypertension, recent MI, CHF, liver failure, renal impairment, DM and glaucoma (including family history), osteoporosis, corneal perforation, severe affective disorders, epilepsy, peptic ulcer, hypothyroidism, pregnancy and lactation.
Antacids, ACE inhibitors, acetazolamide, adrenergic neuron blockers, antidiabetics, aspirin, barbiturate, β-blockers, calcium-channel blockers, carbamazepine, carbenoxolone, cardiac glycosides, clonidine, coumarins, diazoxide, diuretics, erythromycin, hydralazine, ketoconazole, methotrexate, methyldopa, mifepristone, minoxidil, moxonidine, nitrates, nitroprusside, NSAIDs, oestrogens, phenytoin, primidone, rifamycins, ritonavir, somatropin, β2 sympathomimetics, theophylline, vaccines.
Food Interaction: Salad and vegetable diet including alcohol may affect anticoagulant control.
Oral Allergic and inflammatory disorders Adult: Initially, up to 120 mg daily. Maintenance: 3-18 mg/day. Child: 0.25-1.5 mg/kg/day given on alternate days. Hepatic impairment: Dose reductions may be needed.
List of Contraindications
Caution when used during pregnancy
Caution when used during lactation
Systemic infection; live virus vaccines in those receiving immunosuppressive doses
Deflazacort brands in India