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Deflazacort information from DrugsUpdate  

See Available Brands of Deflazacort in India

P - Caution when used during pregnancy
L - Caution when used during lactation
FI - Food *

Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant. Deflazacort is a prodrug. Its potency is around 70?90% that of prednisone.

Pharmacodynamics

Pharmacokinetics

Deflazacort, derived from prednisolone, is a corticosteroid with mainly glucocorticoid activity. An anti-inflammatory dose of 6 mg deflazacort is equiv to 5 mg prednisolone.

Deflazacort Indications / Deflazacort Uses

Information Not Available

Deflazacort Adverse Reactions / Deflazacort Side Effects

GI disturbances, musculoskeletal, endocrine, neuropsychiatric, ophthalmic, fluid and electrolyte disturbances; susceptible to infection, impaired healing, hypersensitivity, skin atrophy, striae, telangiectasia, acne, myocardial rupture following recent MI, thromboembolism.

Precautions

Information Not Available

Special Precautions

Adrenal suppression and infection, child, adolescents, elderly, history of TB and steroid myopathy, hypertension, recent MI, CHF, liver failure, renal impairment, DM and glaucoma (including family history), osteoporosis, corneal perforation, severe affective disorders, epilepsy, peptic ulcer, hypothyroidism, pregnancy and lactation.

Other Drug Interactions

Antacids, ACE inhibitors, acetazolamide, adrenergic neuron blockers, antidiabetics, aspirin, barbiturate, β-blockers, calcium-channel blockers, carbamazepine, carbenoxolone, cardiac glycosides, clonidine, coumarins, diazoxide, diuretics, erythromycin, hydralazine, ketoconazole, methotrexate, methyldopa, mifepristone, minoxidil, moxonidine, nitrates, nitroprusside, NSAIDs, oestrogens, phenytoin, primidone, rifamycins, ritonavir, somatropin, β2 sympathomimetics, theophylline, vaccines.

Other Interactions

Food Interaction: Salad and vegetable diet including alcohol may affect anticoagulant control.

Dosage

Oral Allergic and inflammatory disorders Adult: Initially, up to 120 mg daily. Maintenance: 3-18 mg/day. Child: 0.25-1.5 mg/kg/day given on alternate days. Hepatic impairment: Dose reductions may be needed.

Food(before/after)

Information Not Available

List of Contraindications

Deflazacort and Pregnancy

Caution when used during pregnancy

Deflazacort and Lactation

Caution when used during lactation

Deflazacort and Children

Information Not Available

Deflazacort and Geriatic

Information Not Available

Deflazacort and Other Contraindications

Systemic infection; live virus vaccines in those receiving immunosuppressive doses

Storage

Information Not Available

Lab interference

Information Not Available

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