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Ciclesonide information from DrugsUpdate  

See Available Brands of Ciclesonide in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco for asthma and Omnaris/Omniair for hayfever in the US & Canada. Phase 3 trials for the hayfever indication outside the US are ongoing.

Pharmacodynamics

Pharmacokinetics

Absorption
Prodrug converted to active metabolite, des-ciclesonide, after topical administration. Negligible serum concentrations following intranasal administration. Des-ciclesonide C max below 30 pg/mL.

Distribution
Following IV administration, Vd of ciclesonide and des-ciclesonide are approximately 2.9 and 12.1 L/kg, respectively, and protein binding averages at least 99% for ciclesonide and its metabolite.

Metabolism
Des-ciclesonide is metabolized in the liver by the CYP3A4 isozyme and, to a lesser degree, CYP2D6.

Elimination
After IV administration, predominantly excreted in the feces (66%) and approximately 20% or less in the urine.

Special Populations
Hepatic Function Impairment. When administered by oral inhalation, dosage adjustments are not needed in patients with hepatic function impairment.

Ciclesonide Indications / Ciclesonide Uses

Information Not Available

Ciclesonide Adverse Reactions / Ciclesonide Side Effects

CNS
Headache (7%).

EENT
Nasopharyngitis (7%); epistaxis (5%); pharyngolaryngeal pain (3%); ear pain (2%).

Precautions

Monitor
Closely monitor patients with a change in vision and with a history of glaucoma or cataracts.

Special Precautions

Information Not Available

Other Drug Interactions

Ketoconazole
May increase des-ciclesonide exposure by about 3.6-fold. Coadminister with caution.

Other Interactions

Information Not Available

Dosage

Perennial Allergic Rhinitis Adults and Children 12 years of age and older.
Nasal inhalation 200 mcg/day administered as 2 sprays (50 mcg/spray) in each nostril once daily (max, 200 mcg/day).


Seasonal Allergic Rhinitis Adults and Children 6 years of age and older.
Nasal inhalation 200 mcg/day administered as 2 sprays (50 mcg/spray) in each nostril once daily (max, 200 mcg/day).

Food(before/after)

Information Not Available

List of Contraindications

Ciclesonide and Pregnancy

Caution when used during pregnancy

Ciclesonide and Lactation

Caution when used during lactation

Ciclesonide and Children

Information Not Available

Ciclesonide and Geriatic

Information Not Available

Ciclesonide and Other Contraindications

Standard considerations

Storage

Store at 59° to 86°F. Do not freeze

Lab interference

Store at 59° to 86°F. Do not freeze

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