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Oxazepam information from DrugsUpdate  

See Available Brands of Oxazepam in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation
FI - Food *

Oxazepam (marketed as Alepam, Medopam, Murelax, Noripam, Ox-Pam, Purata, Serax and Serepax), is a drug which is a benzodiazepine derivative. Oxazepam is a benzodiazepine used extensively for the treatment of anxiety and insomnia and in the control of symptoms of alcohol withdrawal. It is a metabolite of diazepam, prazepam and temazepam. Oxazepam has moderate amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties compared to other benzodiazepines.



Oxazepam is a short-acting benzodiazepine. It enhances the activity of GABA, a major inhibitory neurotransmitter in the brain, by binding to specific sites in the GABA receptors.

Well absorbed from the GI tract; peak plasma levels in about 2 hours (oral).

Crosses the placenta and detected in breast milk. Protein-binding: 85-97%.

Hepatic; extensively metabolised to inactive glucuronide.

Via urine as unchanged drug and inactive metabolites. Elimination half-life: 3-21 hours.

Oxazepam Indications / Oxazepam Uses

Information Not Available

Oxazepam Adverse Reactions / Oxazepam Side Effects

The adverse reactions include Syncope (rare), oedema; drowsiness, ataxia, dizziness, vertigo, memory impairment, headache, paradoxical reactions (excitement, stimulation of effect), lethargy, amnesia, euphoria; rash; decreased libido, menstrual irregularities; incontinence; leukopenia, blood dyscrasias; jaundice; dysarthria, tremor, reflex slowing; blurred vision, diplopia; drug dependence.


Although hypotension has occurred only rarely, Oxazepam should be administered with caution to patients in whom a drop in blood pressure might lead to cardiac complications. This is particularly true in the elderly patients.

Symptoms: Somnolence, confusion, coma, hypoactive reflexes, dyspnoea, hypotension, slurred speech, impaired coordination. Treatment: Supportive.

Special Precautions

Cross-sensitivity with other benzodiazepines may occur. Hepatic and renal impairment. Respiratory disease. Debilitated patients, elderly, patients at risk of falls. Withdraw gradually. Porphyria; impaired gag reflex. History of drug abuse or acute alcoholism. May impair ability to drive or operate machinery. CV or cerebrovascular disease, intolerance to transient decreases in BP. Depression or if suicidal risk is present.

Other Drug Interactions

Reduced sedative effects with theophylline and other CNS stimulants. Increased incidence of headache with zidovudine. May reduce effects of levodopa.

Potentially Fatal: Additive CNS depression with alcohol and other CNS depressants.

Other Interactions

Food Interaction
Additive CNS depression may occur with valerian, St John's wort, kava kava, gotu kola.


Alcohol withdrawal syndrome
Adult: 15-30 mg 3 or 4 times daily.
Elderly: or debilitated patients: Initially, 10 mg tid; increase up to 10-20 mg 3 or 4 times daily as necessary.

Adult: 15-30 mg 3 or 4 times daily.
Elderly: or debilitated patients: Initially, 10 mg tid; increase up to 10-20 mg 3 or 4 times daily as necessary.

Insomnia associated with anxiety
Adult: 15-25 mg given 1 hour before bedtime. Up to 50 mg may be occasionally required.


May be taken with or without food

List of Contraindications

Oxazepam and Pregnancy

Contraindicated in pregnancy

Oxazepam and Lactation

Contraindicated in lactation

Oxazepam and Children

Dosage and efficacy not established in children younger than 6 years of age; absolute dosage not established for patients 6 to 12 years of age.

Oxazepam and Geriatic

For elderly and debilitated patients, initial dose should be small; increase gradually.

Oxazepam and Other Contraindications

Not for the treatment of psychoses. Pregnancy and lactation.


Store at 15-30°C (59-86°F).

Lab interference

Store at 15-30°C (59-86°F).

Oxazepam brands in India:

Anxozap Serepax

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