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Orciprenaline information from DrugsUpdate  

See Available Brands of Orciprenaline in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Orciprenaline is a bronchodilator used in the treatment of asthma. Orciprenaline is a moderately selective beta2-adrenergic receptor agonist that stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature supplying skeletal muscle, with minimal or no effect on alpha-adrenergic receptors. The pharmacologic effects of beta adrenergic agonist drugs, such as orciprenaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of ATP to cAMP. Increased cAMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from many cells, especially from mast cells.

Pharmacodynamics

Information Not Available

Pharmacokinetics

Orciprenaline is a direct acting sympathomimetic with predominantly β2-adrenoceptor stimulant activity. It has minimal effect on heart rate.

Onset
Inhaler: Within 1 minutes. Nebuliser: 5-30 minutes. Oral: 15 minutes.

Duration
Up to 6 hours (inhalation).

Absorption
Absorbed from the GI tract (oral).

Metabolism
Hepatic; undergoes extensive first-pass metabolism.

Excretion
Via urine (mainly as metabolites).

Orciprenaline Indications / Orciprenaline Uses

Information Not Available

Orciprenaline Adverse Reactions / Orciprenaline Side Effects

Tachycardia, nervousness, increased serum glucose, increased potassium levels, tremor, palpitation, headache, dizziness, insomnia, nausea, vomiting, bad taste, heartburn, xerostomia, trembling, muscle cramps, weakness, coughing, pharyngitis, increased diaphoresis, paradoxical bronchospasm, hypertension, chest pain, angina, drowsiness, diarrhoea, taste change.

Precautions

Information Not Available

Special Precautions

CV disease (e.g. arrhythmia, hypertension, CHF), DM, glaucoma, hyperthyroidism, hypokalaemia, seizure disorders. Pregnancy and lactation.

Other Drug Interactions

Effects may be antagonised by β-blockers e.g. propranolol. Duration of bronchodilation may be increased with inhaled ipratropium. Increased adverse effects with MAOIs, TCAs, sympathomimetics.

Potentially Fatal: Increased risk of malignant arrhythmias with halothane.

Other Interactions

Information Not Available

Dosage

Oral
Chronic management of reversible airways obstruction
Adult: As sulfate: 20 mg 3 or 4 times daily.
Child: As sulfate: Up to 1 year: 5-10 mg tid; 1-3 years: 5-10 mg 4 times daily; 3-12 years: 40-60 mg daily in divided doses.

Oral

Bradycardia
Adult: As sulfate: Up to 240 mg daily in divided doses.

Intravenous
Bradycardia
Adult: As sulfate: 250-500 mcg by slow IV injection

Inhalation

Acute bronchospasm
Adult: As sulfate: Metered-dose inhaler releasing 750 mcg per inhalation: 1 or 2 inhalations; repeat if necessary. Max: Up to 12 inhalations in 24 hours. As 5% soln from a hand nebuliser: 10 inhalations. With a nebulising device e.g. intermittent positive-pressure breathing (IPPB) apparatus: 0.2-0.3 ml of a 5% solution diluted up to 2.5 ml physiological saline, administered not more often than every 4 hours.
Child: As sulfate: Metered-dose inhaler: >12 years: 1 or 2 inhalations (750 mcg); repeat if necessary after not <3 hours. Max in 24 hours: <6 years: Up to 4 inhalations; 6-12 years: Up to 8 inhalations; >12 years: Up to 12 inhalations. Nebuliser: Infants and children: 0.01-0.02 ml of 5% solution; min dose: 0.1 ml; max dose: 0.3 ml diluted in 2-3 ml normal saline every 4-6 hours or more frequently if necessary.

Food(before/after)

May be taken with or without food.

List of Contraindications

Orciprenaline and Pregnancy

Caution when used during pregnancy

Orciprenaline and Lactation

Caution when used during lactation

Orciprenaline and Children

Information Not Available

Orciprenaline and Geriatic

Inhalation
Metered-dose inhaler: Store at 15-25°C.

Nebuliser
Store below 25°C. Protect from light.

Oral
Store in tight, light-resistant containers at 15-30°C.

Orciprenaline and Other Contraindications

Cardiac arrhythmias associated with tachycardia.

Storage

Inhalation
Metered-dose inhaler: Store at 15-25°C.

Nebuliser
Store below 25°C. Protect from light.

Oral
Store in tight, light-resistant containers at 15-30°C.

Lab interference

Inhalation
Metered-dose inhaler: Store at 15-25°C.

Nebuliser
Store below 25°C. Protect from light.

Oral
Store in tight, light-resistant containers at 15-30°C.

Orciprenaline brands in India:

Alupent

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