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Chlorphenamine information from DrugsUpdate  

See Available Brands of Chlorphenamine in India

P - Caution when used during pregnancy
L - Caution when used during lactation
FI - Food *

Chlorpheniramine, commonly marketed as its salt chlorphenamine maleate (CPM; Chlor-Trimeton, Piriton, Chlor-Tripolon), is a first-generation alkylamine antihistamine used in the prevention of the symptoms of allergic conditions such as rhinitis and urticaria. Its sedative effects are relatively weak compared to other first-generation antihistamines. Chlorpheniramine is one of the most commonly-used antihistamines in small-animal veterinary practice as well. Although not generally approved as an antidepressant or anti-anxiety medication, chlorpheniramine appears to have these properties as well.

 

Chlorpheniramine is part of a series of antihistamines including pheniramine (Naphcon) and its halogenated derivatives and others including fluorpheniramine, dexchlorpheniramine (Polaramine), brompheniramine (Dimetapp), dexbrompheniramine (Drixoral), deschlorpheniramine, dipheniramine (also known as triprolidine with the trade name Actifed), and iodopheniramine.
The halogenated alkylamine antihistamines all exhibit optical isomerism, and chlorpheniramine in the indicated products is racemic chlorpheniramine maleate, whereas dexchlorpheniramine (Polaramine) is the dextrorotary (right-handed) stereoisomer.
It is also known as Comakin in Taiwan and parts of Asia.

Pharmacodynamics

Pharmacokinetics

Chlorphenamine is an H1-receptor antagonist which competetively blocks H1-receptor sites on tissues.

Duration
4-6 hours

Absorption
Absorbed relatively slowly from the GI tract (oral); peak plasma concentrations after 2.5-6 hours.

Distribution
Widely distributed; CNS. Protein-binding: 70%.

Metabolism
Extensive; converted to desmethyl- and didesmethylchlorphenamine.

Excretion
Via urine (as unchanged drug and metabolites).

Chlorphenamine Indications / Chlorphenamine Uses

Information Not Available

Chlorphenamine Adverse Reactions / Chlorphenamine Side Effects

CNS depression, sedation, drowsiness, lassitude, dizziness. GI upsets, anorexia, or increased appetite, epigastric pain, blurring of vision, dysuria, dryness of mouth, tightness in chest, hypotension, muscular weakness, tinnitus, euphoria, headache, paradoxical CNS stimulation.


Potentially Fatal: CV collapse and respiratory failure.

Precautions

Information Not Available

Special Precautions

Elderly, pylori duodenal obstruction, angle-closure glaucoma, urinary retention, prostatic hyperplasia, epilepsy, renal and hepatic impairment. May affect performance of skilled tasks. BPH, bladder neck obstruction, hypertension. Pregnancy, lactation.

Other Drug Interactions

Potentiates sedative effect of psychotropic drugs e.g. barbiturates, hypnotics, opiod analgesics, anxiolytics and antipsychotics. Interaction with alcohol could be dangerous (sedation/excitation).

Other Interactions

Food Interactions: Reduced bioavailability

Dosage

Oral Allergic conditions
Adult: 4 mg every 4-6 hours. Max: 24 mg daily.
Child: 1-2 years: 1 mg bid, 2-5 years: 1 mg every 4-6 hours, 6-12 years: 2 mg every 4-6 hours. Max: 6 mg daily (1-5 years); 12 mg daily (6-12 years).

Parenteral Adjunct in the emergency treatment of anaphylactic shock
Adult: 10-20 mg IM, SC, or slow IV injection over 1 minute. Max dose: 40 mg daily.
Child: 87.5 mcg/kg SC 4 times daily


Incompatibility
Incompatible with calcium chloride, kanamycin sulfate, noradrenaline acid tartrate, pentobarbital sodium and meglumine adipiodone.

Food(before/after)

May be taken with or without food

List of Contraindications

Chlorphenamine and Pregnancy

Caution when used during pregnancy


Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Chlorphenamine and Lactation

Caution when used during lactation

Chlorphenamine and Children

Information Not Available

Chlorphenamine and Geriatic

Information Not Available

Chlorphenamine and Other Contraindications

Hypersensitivity, neonates

Storage

Oral
Store below 25°C.

Parenteral
Store below 25°C.

Lab interference

Oral
Store below 25°C.

Parenteral
Store below 25°C.

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