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Nitazoxanide information from DrugsUpdate  

See Available Brands of Nitazoxanide in India

P - Caution when used during pregnancy
L - Caution when used during lactation
FI - Food *

Nitazoxanide, also known by the brand names Alinia and Annita (and by Daxon, Dexidex, Kidonax, Pacovanton and Paramix in Mexico, by Nitax, Zox, Nitazox and Toza in Bangladesh) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent.

Nitazoxanide is a light yellow crystalline powder. It is poorly soluble in ethanol and practically insoluble in water.

Pharmacodynamics

Pharmacokinetics

Nitazoxanide is an antiprotozoal agent. Both nitazoxanide and its active metabolite (tizoxanide) interfere with the pyruvate:ferredoxin 2-oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic metabolism in susceptible organisms.

Absorption

Absorbed from the GI tract (oral). Extent of absorption enhanced with food; peak plasma concentrations of tizoxanide and glucuronide metabolite after 1-4 hours.

Distribution
Protein-binding: >99%.

Metabolism

Rapidly hydrolysed to tizoxanide (active desacetyl metabolite) which partially undergoes conjugation, primarily by glucuronidation.

Excretion
Via faeces (2/3 of an oral dose); via urine (remaining dose).

Nitazoxanide Indications / Nitazoxanide Uses

Information Not Available

Nitazoxanide Adverse Reactions / Nitazoxanide Side Effects

Headache, abdominal pain, diarrhoea, nausea, vomiting, allergic reactions, anaemia, anorexia, increased appetite, increased creatinine and LFT, diaphoresis, dizziness, eye and urine discolouration, fever, flatulence, hypertension, infection, malaise, nausea, pruritus, rhinitis, enlarged salivary glands, tachycardia.

Precautions

Information Not Available

Special Precautions

Renal and hepatic impairment. Pregnancy and lactation. Children <1 year.

Other Drug Interactions

May possibly interact with highly protein-bound drugs e.g. warfarin.

Other Interactions

Food Interaction
Increased AUC with food.

Dosage

Oral
Cryptosporidiosis, Giardiasis
Adult: 500 mg every 12 hours for 3 days.
Child: 1-3 years: 100 mg every 12 hours; 4-11 years: 200 mg every 12 hours; ≥12 years: 500 mg every 12 hours. All doses to be taken for 3 days.

Food(before/after)

Should be taken with food.

List of Contraindications

Nitazoxanide and Pregnancy

Caution when used during pregnancy

Nitazoxanide and Lactation

Caution when used during lactation

Nitazoxanide and Children

Safety and efficacy not established for treatment of C. parvum in patients 12 years of age and older.


Oral suspension
Safety and efficacy not established in children younger than 1 year of age.

Tablets
Not for use in children 11 years of age or younger.

Nitazoxanide and Geriatic

Use with caution because of the greater frequency of decreased hepatic, renal, or cardiac function, and concomitant diseases or other drug therapy.

Nitazoxanide and Other Contraindications

Hypersensitivity

Storage

Oral
Suspension: Store at 15-30°C (59-86°F).

Tablet

Store at room temperature.

Lab interference

Oral
Suspension: Store at 15-30°C (59-86°F).

Tablet

Store at room temperature.

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