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Nicergoline information from DrugsUpdate  

See Available Brands of Nicergoline in India

P - Caution when used during pregnancy

Nicergoline is an ergoloid mesylate derivative used to treat senile dementia and other disorders with vascular origins. It has been found to increase mental agility and enhance clarity and perception. It decreases vascular resistance and increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells. It has similar vasoactive properties in other areas of the body, particularly the lungs.

It is used for vascular disorders such as cerebral thrombosis and atherosclerosis, arterial blockages in the limbs, Raynaud's disease, vascular migraines, and retinopathy.

Nicergoline has been registered in over fifty countries and has been used for more than three decades for the treatment of cognitive, affective, and behavioral disorders of older people.

It is marketed under the trade name Sermion.

Pharmacodynamics

Pharmacokinetics

Nicergoline is an ergot derivative. It has α-adrenergic blocking activity and produces vasodilatation.

Onset
1-1.5 hours(oral).

Absorption
Rapidly absorbed from the GI tract (oral).

Distribution
Protein-binding: 82-87%.

Metabolism

Undergoes significant 1st-pass effect.

Excretion

Via urine (80%), via faeces (20%).

Nicergoline Indications / Nicergoline Uses

Information Not Available

Nicergoline Adverse Reactions / Nicergoline Side Effects

GI disturbances; hypotension (especially after parenteral admin). Hot flushes, malaise, hyperacidity, nausea, diarrhoea, dizziness, somnolence.

Precautions

Information Not Available

Special Precautions

Porphyria. Pregnancy.

Other Drug Interactions

May potentiate action of antihypertensives. May increase cardiac depressant effects of propranolol.

Other Interactions

Information Not Available

Dosage

Oral
Mental deterioration associated with cerebrovascular insufficiency
Adult: 10 mg tid. Maintenance: 5-10 mg tid. Max: Up to 60 mg daily in divided doses.
Renal impairment: Reduce dose.

Oral

Peripheral vascular disease
Adult: 10 mg tid. Maintenance: 5-10 mg tid. Max: Up to 60 mg daily in divided doses.
Renal impairment: Reduce dose.

Intravenous

Symptoms of mental deterioration associated with cerebrovascular insufficiency
Adult: 4-8 mg by slow IV infusion (over 30 minutes).
Renal impairment: Reduce dose.

Intravenous
Peripheral vascular disease
Adult: 4-8 mg by slow IV infusion (over 30 min).
Renal impairment: Reduce dose.

Intramuscular

Symptoms of mental deterioration associated with cerebrovascular insufficiency
Adult: 2-4 mg bid.
Renal impairment: Reduce dose.

Intramuscular
Peripheral vascular disease
Adult: 2-4 mg bid.
Renal impairment: Reduce dose.

Reconstitution

Dilute in 250 ml saline solution.

Food(before/after)

Should be taken on an empty stomach. (Take on an empty stomach.)

List of Contraindications

Nicergoline and Pregnancy

Caution when used during pregnancy

Nicergoline and Lactation

Information Not Available

Nicergoline and Children

Information Not Available

Nicergoline and Geriatic

Information Not Available

Nicergoline and Other Contraindications

Information Not Available

Storage

Information Not Available

Lab interference

Information Not Available

Nicergoline brands in India:

Cholergol Nicerbium Sermion

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