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Mupirocin information from DrugsUpdate  

See Available Brands of Mupirocin in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Mupirocin (Bactroban or Centany) is an antibiotic originally isolated from Pseudomonas fluorescens NCIMB 10586, developed by Beecham.

Mupirocin is bacteriostatic at low concentrations and bactericidal at high concentrations. It is used topically and is effective against Gram-positive bacteria, including MRSA. Mupirocin is a mixture of several pseudomonic acids, with pseudomonic acid A (PA-A) constituting greater than 90% of the mixture. Also present in mupirocin are pseudomonic acid B with an additional hydroxyl group at C8, pseudomonic acid C with a double bond between C10 and C11, instead of the epoxide of PA-A, and pseudomonic acid D with a double bond at C4` and C5` in the 9-hydroxy-nonanoic acid portion of mupirocin.

Pharmacodynamics

Pharmacokinetics

Mupirocin inhibits protein synthesis of the bacteria by binding to isoleucyl transfer RNA-synthetase. It is active against gram-positive and some gram-negative bacteria.

Absorption
Minimal systemic absorption through intact skin (<0.3%).

Distribution
Protein-binding: 95%

Metabolism
Hepatic, converted to monic acid.

Excretion
Urine; 17-36 minutes (elimination half-life).

Mupirocin Indications / Mupirocin Uses

Information Not Available

Mupirocin Adverse Reactions / Mupirocin Side Effects

Burning, stinging, pain, itching, erythema, dryness, tenderness, dermatitis and rash.

Precautions

Information Not Available

Special Precautions

Mucosal surfaces of eye; renal impairment; extensive burns or open wounds. Pregnancy, lactation, children <3 months.

Other Drug Interactions

Information Not Available

Other Interactions

Information Not Available

Dosage

Topical/Cutaneous
Impetigo
Adult: Apply a 2% ointment tid for 10 days. If no improvement is seen after 3-5 days, consider alternative treatment.
Child: Apply a 2% ointment tid for 10 days. If no improvement is seen after 3-5 days, consider alternative treatment.

Topical/Cutaneous

Secondary skin infections
Adult: Apply a 2% cream tid for 10 days. If no improvement is seen after 3-5 days, consider alternative treatment.
Child: Apply a 2% ointment tid for 10 days. If no improvement is seen after 3-5 days, consider alternative treatment.

Nasal

Eradication of nasal colonisation with Staphylococci aureus
Adult: As 2% nasal ointment: Apply into each nostril bid-tid for a max of 7 days. After application, the nostrils should be closed by pressing together and releasing the sides of the nose.
Child: Adolescents (≥12 years): Apply nasal ointment to the inner surface of both nostrils 2-3 times daily for 5-14 days. After application, the nostrils should be closed by pressing together and releasing the sides of the nose for approximately 1 minute.

Food(before/after)

Information Not Available

List of Contraindications

Mupirocin and Pregnancy

Caution when used during pregnancy

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Mupirocin and Lactation

Caution when used during lactation

Mupirocin and Children

Information Not Available

Mupirocin and Geriatic

Information Not Available

Mupirocin and Other Contraindications

Hypersensitivity to mupirocin or polyethylene glycol.

Storage

Nasal
Store at or below 25°. Do not freeze.

Topical/Cutaneous

Store at or below 25°. Do not freeze.

Lab interference

Nasal
Store at or below 25°. Do not freeze.

Topical/Cutaneous

Store at or below 25°. Do not freeze.

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