Mometasone information from DrugsUpdate
L - Caution when used during lactation
Mometasone furoate (also referred to as mometasone) is a glucocorticoid steroid used topically to reduce inflammation of the skin or in the airways.
Mometasone depresses the formation, release and activity of endogenous inflammatory chemical mediators (e.g. kinins, histamine, liposomal enzymes and prostaglandin). It inhibits the margination and subsequent cell migration to the injury site, reverses vascular dilatation and permeability, resulting in decreased access of cells to the area of injury.
Ointment: 0.7%; increased with occlusive dressings. Nasal spray: Undetectable in plasma. Oral inhalation: <1%.
Via faeces, bile, urine.
Nasal/Oral inhalation: Headache, fatigue, depression; musculoskeletal pain, arthalgia; sinusitis, rhinitis, upper respiratory infection, pharyngitis, cough, epistaxis; viral infection, nasal and oral candidiasis; chest pain; abdominal pain, dry throat, vomiting, diarrhoea, dyspepsia, flatulence, gastroenteritis, nausea, vomiting; dysmenorrhoea; back pain, myalgia; conjunctivitis; earache, otitis media; asthma, bronchitis, dysphonia; nasal irritation, burning and septal perforation; wheezing; nasal ulcers; growth suppression. Topical: Bacterial skin infection, burning, furunculosis, pruritus, skin atrophy, tingling/stinging, folliculitis, moniliasis, paraesthesia, skin depigmentation, rosacea, cataract, growth suppression.
Potentially Fatal: Adrenal suppression, immunosuppression, Kaposi's sarcoma in prolonged periods, anaphylaxis.
Because nasal and inhaled corticosteroids have been associated with glaucoma and cataracts, closely follow patients with changes in vision and a history of glaucoma and/or cataracts. Monitor growth and development of children on prolonged therapy.
Systemic corticosteroid effects.
Discontinue if irritation or sensitisation occurs. Systemic absorption increases when area of application is extensive or an occlusive dressing is used. Pregnancy and lactation. DM, hepatic and renal diseases, myasthenia gravis, CV disease, ocular diseases, osteoporosis, GI diseases, history of seizure disorders. Not for status asthmaticus or relief of acute bronchospasm. Requires dosage adjustments with thyroid status. May reduce growth velocity in children; monitor growth. Taper withdrawal.
Increased risk of hypokalaemia with amphotericin B, potassium-wasting diuretics. Decreases hypoglycaemic effects of antidiabetic drugs. Increased serum levels with antifungals (imidazole). Increased risk of tendinopathies with fluoroquinolones.
Adult: As 0.1% cream/ointment/lotion: Apply onto the affected areas as directed.
Child: Cream/Ointment: ≥2 years: Apply thin film to affected area once daily. Do not use for > 3 weeks. Lotion: ≥12 years: Apply a few drops to affected area once daily.
Treatment and prophylaxis of allergic rhinitis
Adult: 100 mcg in each nostril once daily, increased to 200 mcg into each nostril once daily if needed. Maintenance: 50 mcg in each nostril daily.
Child: 2-11 years: 50 mcg in each nostril daily; ≥12 years: 100 mcg in each nostril daily.
Adult: 100 mcg in each nostril once daily; may increase to bid after 5-6 weeks if needed.
Adult: Mild to moderate: Initially, 400 mcg once daily in the evening. Maintenance: 200 mcg once to bid. Severe: Initially, 400 mcg bid, then titrated to lowest effective dose once controlled.
Child: Mild to moderate: Initially, 400 mcg once daily. Maintenance: 200 mcg once to bid. Severe: Initially, 400 mcg bid, then titrated to lowest effective dose once controlled.
List of Contraindications
Caution when used during pregnancy
Caution when used during lactation
May be more susceptible to topical corticosteroid–induced HPA axis suppression and Cushing syndrome. Children may be more susceptible to corticosteroid-induced HPA suppression.
No difference in safety and efficacy have been noted in patients 65 years of age and older compared with younger patients.
Store at 15-30°C. Discard when counter reads "0" or 45 days after opening.
Store at 15-30°C. Protect from light.
Cream: Store at 2-25°C.
Store at 2-30°C.
Store at 15-30°C.
Mometasone brands in India