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Mometasone information from DrugsUpdate  

See Available Brands of Mometasone in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Mometasone furoate (also referred to as mometasone) is a glucocorticoid steroid used topically to reduce inflammation of the skin or in the airways.

Pharmacodynamics

Pharmacokinetics

Mometasone depresses the formation, release and activity of endogenous inflammatory chemical mediators (e.g. kinins, histamine, liposomal enzymes and prostaglandin). It inhibits the margination and subsequent cell migration to the injury site, reverses vascular dilatation and permeability, resulting in decreased access of cells to the area of injury.

Absorption

Ointment: 0.7%; increased with occlusive dressings. Nasal spray: Undetectable in plasma. Oral inhalation: <1%.

Distribution
Protein-binding: 98-99%.

Metabolism

Hepatic.

Excretion
Via faeces, bile, urine.

Mometasone Indications / Mometasone Uses

Information Not Available

Mometasone Adverse Reactions / Mometasone Side Effects

Nasal/Oral inhalation: Headache, fatigue, depression; musculoskeletal pain, arthalgia; sinusitis, rhinitis, upper respiratory infection, pharyngitis, cough, epistaxis; viral infection, nasal and oral candidiasis; chest pain; abdominal pain, dry throat, vomiting, diarrhoea, dyspepsia, flatulence, gastroenteritis, nausea, vomiting; dysmenorrhoea; back pain, myalgia; conjunctivitis; earache, otitis media; asthma, bronchitis, dysphonia; nasal irritation, burning and septal perforation; wheezing; nasal ulcers; growth suppression. Topical: Bacterial skin infection, burning, furunculosis, pruritus, skin atrophy, tingling/stinging, folliculitis, moniliasis, paraesthesia, skin depigmentation, rosacea, cataract, growth suppression.

Potentially Fatal: Adrenal suppression, immunosuppression, Kaposi's sarcoma in prolonged periods, anaphylaxis.

Precautions

Monitor
Because nasal and inhaled corticosteroids have been associated with glaucoma and cataracts, closely follow patients with changes in vision and a history of glaucoma and/or cataracts. Monitor growth and development of children on prolonged therapy.

Overdosage

Systemic corticosteroid effects.

Special Precautions

Discontinue if irritation or sensitisation occurs. Systemic absorption increases when area of application is extensive or an occlusive dressing is used. Pregnancy and lactation. DM, hepatic and renal diseases, myasthenia gravis, CV disease, ocular diseases, osteoporosis, GI diseases, history of seizure disorders. Not for status asthmaticus or relief of acute bronchospasm. Requires dosage adjustments with thyroid status. May reduce growth velocity in children; monitor growth. Taper withdrawal.

Other Drug Interactions

Increased risk of hypokalaemia with amphotericin B, potassium-wasting diuretics. Decreases hypoglycaemic effects of antidiabetic drugs. Increased serum levels with antifungals (imidazole). Increased risk of tendinopathies with fluoroquinolones.

Other Interactions

Information Not Available

Dosage

Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: As 0.1% cream/ointment/lotion: Apply onto the affected areas as directed.
Child: Cream/Ointment: ≥2 years: Apply thin film to affected area once daily. Do not use for > 3 weeks. Lotion: ≥12 years: Apply a few drops to affected area once daily.

Nasal

Treatment and prophylaxis of allergic rhinitis
Adult: 100 mcg in each nostril once daily, increased to 200 mcg into each nostril once daily if needed. Maintenance: 50 mcg in each nostril daily.
Child: 2-11 years: 50 mcg in each nostril daily; ≥12 years: 100 mcg in each nostril daily.

Nasal

Nasal polyps
Adult: 100 mcg in each nostril once daily; may increase to bid after 5-6 weeks if needed.

Inhalation

Asthma prophylaxis
Adult: Mild to moderate: Initially, 400 mcg once daily in the evening. Maintenance: 200 mcg once to bid. Severe: Initially, 400 mcg bid, then titrated to lowest effective dose once controlled.
Child: Mild to moderate: Initially, 400 mcg once daily. Maintenance: 200 mcg once to bid. Severe: Initially, 400 mcg bid, then titrated to lowest effective dose once controlled.

Food(before/after)

Information Not Available

List of Contraindications

Mometasone and Pregnancy

Caution when used during pregnancy

Mometasone and Lactation

Caution when used during lactation

Mometasone and Children

May be more susceptible to topical corticosteroid–induced HPA axis suppression and Cushing syndrome. Children may be more susceptible to corticosteroid-induced HPA suppression.

Mometasone and Geriatic

No difference in safety and efficacy have been noted in patients 65 years of age and older compared with younger patients.

Mometasone and Other Contraindications

Information Not Available

Storage

Inhalation
Store at 15-30°C. Discard when counter reads "0" or 45 days after opening.

Nasal
Store at 15-30°C. Protect from light.

Topical/Cutaneous
Cream: Store at 2-25°C.

Lotion

Store at 2-30°C.

Ointment
Store at 15-30°C.

Lab interference

Inhalation
Store at 15-30°C. Discard when counter reads "0" or 45 days after opening.

Nasal
Store at 15-30°C. Protect from light.

Topical/Cutaneous
Cream: Store at 2-25°C.

Lotion

Store at 2-30°C.

Ointment
Store at 15-30°C.

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