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Mizolastine information from DrugsUpdate  

See Available Brands of Mizolastine in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Mizolastine is a once daily, non-sedating antihistamine. It blocks histamine H1 receptors and is commonly fast-acting. It does not prevent the actual release of histamine from mast cells, just prevents it binding to receptors. Side effects can include dry mouth and throat. May also result, in some patients, in dream disturbance or enhancement - this despite not causing drowsiness nor passing into the brain.

Pharmacodynamics

Pharmacokinetics

Mizolastine, a non-sedating antihistamine, blocks histamine H1-receptors on effector cells of the GI tract, blood vessels and respiratory tract. It also has mast-cell stabilising properties.

Absorption

Absorbed rapidly from the GI tract (oral); peak plasma concentrations after 1.5 hours.

Distribution
Protein-binding: 98%.

Metabolism

By glucuronidation (main pathway) or by cytochrome P450 isoenzyme CYP3A4 forming inactive hydroxylated metabolites.

Excretion

13 hours (elimination half-life).

Mizolastine Indications / Mizolastine Uses

Information Not Available

Mizolastine Adverse Reactions / Mizolastine Side Effects

Dry mouth, diarrhoea, abdominal pain, nausea; transient drowsiness, headache, dizziness; anxiety and depression; raised liver enzymes: low neutrophil count; transient asthenia, increased appetite associated with wt gain; allergic reactions e.g. angioedema, generalised rash/urticaria, pruritus and hypotension; tachycardia, palpitations; vasovagal attack; arthralgia and myalgia.

Potentially Fatal: Anaphylaxis.

Precautions

Information Not Available

Special Precautions

May impair ability to drive or operate machinery. Elderly. Pregnancy (avoid in 1st trimester) and lactation.

Other Drug Interactions

Antidepressants and anxiolytics may enhance sedative effect. Potent inhibitors of or substrates for the hepatic metabolism of mizolastine (e.g. cimetidine, ciclosporin, nifedipine) may alter its metabolism.

Potentially Fatal: Increased risk of cardiac arrhythmias with drugs known to prolong the QT interval e.g. class I and III antiarryhthmics. Increased plasma concentrations with macrolide antibiotics and imidazole antifungals.

Other Interactions

Information Not Available

Dosage

Oral
Allergic conditions
Adult: 10 mg daily.
Child: ≥12 years: 10 mg daily.
Elderly: 10 mg daily.

Food(before/after)

Information Not Available

List of Contraindications

Mizolastine and Pregnancy

Caution when used during pregnancy

Mizolastine and Lactation

Caution when used during lactation

Mizolastine and Children

Information Not Available

Mizolastine and Geriatic

Information Not Available

Mizolastine and Other Contraindications

Caution when used during lactation Significant cardiac or hepatic disease; electrolyte imbalance, particularly hypokalaemia; known or suspected QT prolongation. Clinically significant bradycardia.

Storage

Oral
Do not store above 25°C.

Lab interference

Oral
Do not store above 25°C.

Mizolastine brands in India:

Elina Zehist

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