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Mesterolone information from DrugsUpdate  

See Available Brands of Mesterolone in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation
LI - Lab *

Mesterolone is an orally applicable androgen, and DHT derivative. It is sold under the brand name Proviron, by Schering.

Mesterolone is a relatively weak androgen and rarely used for replacement therapies.

Pharmacodynamics

Pharmacokinetics

Mesterolone is an androgen with less inhibitory effects on intrinsic testicular function compared to testosterone.

Absorption

Rapidly and almost completely absorbed (oral); peak serum levels in about 1.6 hours.

Distribution
Protein-binding: About 40% to albumin and 58% to sex-hormone binding globulin.

Metabolism
Rapidly metabolised; absolute bioavailability: 3% of the oral dose. Not metabolised to oestrogenic compounds.

Excretion
Via urine (approx 77% of the metabolites); via faeces (approx 13%); 12-13 hours (terminal half-life).

Mesterolone Indications / Mesterolone Uses

Information Not Available

Mesterolone Adverse Reactions / Mesterolone Side Effects

Frequent or persistent erections.

Potentially Fatal: Malignant liver tumours.

Precautions

Information Not Available

Special Precautions

Regularly examine the prostate and breast during treatment. CV disorders, renal or hepatic impairment, epilepsy, migraine, DM or other conditions that may be exacerbated by the possible fluid retention or oedema. Skeletal metastases (risk of hypercalcaemia). Children. Monitor skeletal maturation during therapy.

Other Drug Interactions

Enhances effects of ciclosporin, antidiabetics, levothyroxine, anticoagulants e.g. warfarin. Resistance to the effects of neuromuscular blockers may occur.

Other Interactions

Information Not Available

Dosage

Oral
Androgen deficiency, Infertility due to hypogonadism
Adult: Initially, 75-100 mg daily in divided doses. Maintenance: 50-75 mg daily in divided doses.

Food(before/after)

May be taken with or without food

List of Contraindications

Mesterolone and Pregnancy

Contraindicated in pregnancy

Mesterolone and Lactation

Contraindicated in lactation

Mesterolone and Children

Information Not Available

Mesterolone and Geriatic

Information Not Available

Mesterolone and Other Contraindications

Prostatic or breast carcinoma. Previous or existing hepatic tumours. Pregnancy and lactation.

Storage

Information Not Available

Lab interference

Information Not Available

Mesterolone brands in India:

Mestilon Provironum Restore

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