Drugsupdate.com is up for sale. To own one of the most recognized online brands by doctors in India with millions of visitors - click here.

logo image

Meropenem information from DrugsUpdate  

See Available Brands of Meropenem in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Meropenem, an antibiotic is prescribed for the treatment of intra-abdominal infections including appendicitis, peritonitis, bacterial meningitis, nosocomial pneumonia (hospital-acquired), skin and soft tissue infections in adults and children.

Pharmacodynamics

Meropenem exerts bactericidal activity by penetrating into the microbial cells and by interfering with the biosynthesis of vital cell wall biochemicals that lead to cell death.

Pharmacokinetics

Plasma clearance of Meropenem is directly correlated with renal creatinine clearance rate. Impaired renal clearance of Meropenem is reported in kidney disorder patients and elderly patients. Intravenously administered Meropenem can be cleared by hemodialysis. No need for an adjusted dose of Meropenem in hepatic disorder patients. 

Meropenem Indications / Meropenem Uses

Information Not Available

Meropenem Adverse Reactions / Meropenem Side Effects

Diarrhoea, nausea, vomiting, abdominal pain; headache; constipation; rash, pruritus, uticaria; apnoea; phlebitis, thrombophlebitis, swelling and pain at inj site; disturbances in LFTs (may cause increases in serum transaminases, alkaline phosphatase, lactic dehydrogenase). Rarely: erythema multiforme; eosinophilia, thrombocytopenia, leucopenia, neutropenia; seizures and CNS effects reported in patients with underlying CNS disorders or renal impairment.

Potentially Fatal: Anaphylaxis; pseudomembranous colitis; Stevens-Johnsons sydrome.

Precautions

Meropenem should be administered to patients with allergy to Penicillin antibiotics, Cephalosporin, Imipenem and Meropenem. Meropenem is contraindicated in patients with renal diseases, brain tumor, head injury and seizures. An adjusted dosage may be needed in such patients.

Special Precautions

History of hypersensitivity to carbapenem, pencillins or other β-lactam antibiotics; infants <3 months; renal insufficiency; neurological disorders; pregnancy, lactation. Not recommended for use in MRSA.

Other Drug Interactions

Serum levels may be increased by probenecid. May reduce serum valproic acid levels; sub-therapeutic levels may be reached in some patients.

Other Interactions

Information Not Available

Dosage

For Intra-abdominal Infection (Adults):
Administer 1 g of Meropenem, IV, thrice daily for 7 to 14 days.

For Meningitis (Adults):
Administer 1-2 g of Meropenem, IV, thrice daily for 7 to 21 days

For Nosocomial Pneumonia (Adults):
Administer 1 gm of Meropenem, IV, every 8 hours. Empirical therapy with broad-spectrum antibiotics and on antibiogram is recommended in multi-drug resistant infections. In Pseudomonas aeruginosa negative infections, the treatment should be restricted to less than 7 days.

For Skin or Soft Tissue Infection (Adults):
For complication infections, administer 500 mg IV, every 8 hours. The treatment should be continued for at least 7-10 days or for three days after the onset of inflammation. In case of severe infections including diabetic soft tissue infections, 14-21 days treatment should be considered.
 
For Intra-abdominal Infection (Pediatric):
For children 3 months and older, consider administration of 20 mg/kg Meropenem, IV, every 8 hours. The maximum dose should not exceed 3 g/day. For children with body weight 50 kg and over, 1 g of Meropenem should be administered intravenously every 8 hours.
 
For Meningitis (Pediatric):
For children 3 months and older, consider administration of 40 mg/kg Meropenem, IV, every 8 hours. The maximum dose should not exceed 6 g/day. For children with body weight 50 kg and over, 2 g of Meropenem should be administered intravenously every 8 hours.
 
For Complicated Skin and Structure Infection (Pediatric):
For children 3 months and older, consider administration of 10 mg/kg Meropenem, IV, every 8 hours. The maximum dose should not exceed 1.5 g/day. For children with body weight 50 kg and over, 500 mg of Meropenem should be administered intravenously every 8 hours.

Food(before/after)

Information Not Available

List of Contraindications

Meropenem and Pregnancy

USFDA pregnancy category B. Meropenem may not cause harm to an unborn foetus. Before Meropenem treatment, the patient should discuss with the physician, if they are planning for a pregnancy.

Meropenem and Lactation

It is unclear whether the drug could pass through the breast milk to a breast feeding a baby. Consult your physician before taking Meropenem, if you are nursing mother.

Meropenem and Children

Safety and efficacy in children 3 months of age and younger not established.

Meropenem and Geriatic

Use care in dose selection because elderly patients are more likely to have decreased renal function; monitor renal function.

Meropenem and Other Contraindications

Hypersensitivity

Storage

Store at 20-25°C.

Lab interference

Store at 20-25°C.

© 2011-2019 DrugsUpdate.com. Disclaimer | Site Map

Feedback
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.