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Mephentermine information from DrugsUpdate  

See Available Brands of Mephentermine in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Mephentermine is a cardiac stimulant. It was formerly used in Wyamine nasal decongestant inhalers and before that as a stimulant in psychiatry.

It has been used as a treatment for hypotension.



Mephentermine appears to act by indirect stimulation of β-adrenergic receptors causing the release of norepinephrine from its storage sites. It has a positive inotropic effect on the myocardium. AV conduction and refractory period of AV node is shortened with an increase in ventricular conduction velocity. It dilates arteries and arterioles in the skeletal muscle and mesenteric vascular beds, leading to an increase in venous return.

5-15 minutes (IM), immediate (IV).

4 hours (IM), 30 minutes (IV).


Rapidly demethylated in the body followed by hydroxylation.

Via urine (as unchanged and metabolites); more rapid in acidic urine.

Mephentermine Indications / Mephentermine Uses

Information Not Available

Mephentermine Adverse Reactions / Mephentermine Side Effects

Drowsiness, incoherence, hallucinations, convulsions, tachycardia. Fear, anxiety, restlessness, tremor, insomnia, confusion, irritability and psychosis. Nausea, vomiting, reduced appetite, urinary retention, dyspnoea, weakness.

Potentially Fatal: AV block, CNS stimulation. Cerebral haemorrhage and pulmonary oedema, ventricular arrhythmias.


Information Not Available

Special Precautions

Patient on MAOIs. For shock due to loss of blood or fluid, give fluid replacement therapy primarily, CVS disease, hypertension, hyperthyroidism, chronic illnesses. Lactation, pregnancy.

Other Drug Interactions

Antagonises effect of hypotensive agents. Severe hypertension with MAOIs and possibly TCAs. Additive vasoconstricting effects with ergot alkaloids, oxytocin.

Potentially Fatal: Risk of arrhythmia in patients undergoing anesthesia with cyclopropane and halothane.

Other Interactions

Information Not Available


Maintenance of blood pressure in hypotensive states
Adult: 30-45 mg as a single dose, repeated as necessary or followed by IV infusion of 0.1% mephentermine in 5% dextrose, rate and duration of administration will depend on patient's response.

Hypotension secondary to spinal anaesthesia in obstetric patients
Adult: 15 mg as a single dose, repeat if needed.


Information Not Available

List of Contraindications

Mephentermine and Pregnancy

Caution when used during pregnancy

Mephentermine and Lactation

Caution when used during lactation

Mephentermine and Children

Information Not Available

Mephentermine and Geriatic

Information Not Available

Mephentermine and Other Contraindications

Hypotension caused by phenothiazines. Hypertension. Phaeochromocytoma.


Information Not Available

Lab interference

Information Not Available

Mephentermine brands in India:

Mephentine Termin

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