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Lornoxicam information from DrugsUpdate  

See Available Brands of Lornoxicam in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Lornoxicam (chlortenoxicam) is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory and antipyretic properties. It is available in oral and parenteral formulations.

Pharmacodynamics

Pharmacokinetics

Lornoxicam is an NSAID that is used in musculoskeletal, joint disorders and other painful conditions including postoperative pain. Lornoxicam is a potent inhibitor of both COX-1 and COX-2 enzymes.

Absorption
Extensively absorbed from the GI tract. Peak plasma concentration within 1-2 hours (oral) or 25 min (IM).

Distribution
99% bound to plasma proteins.

Metabolism

Metabolised to its inactive metabolite.

Excretion

Excreted in the faeces (as metabolites) and urine (as unchanged drug). Mean elimination half life of 3-4 hours.

Lornoxicam Indications / Lornoxicam Uses

Information Not Available

Lornoxicam Adverse Reactions / Lornoxicam Side Effects

Abdominal pain, diarrhoea, dizziness, dyspepsia, nausea, vomiting; headache; haematologic disorders; CNS effects; visual disturbance; tinnitus; nephrotoxicity; fluid retention; photosensitivity; alveolitis; pancreatitis; Stevens-Johnson syndrome; toxic epidermal necrolysis; colitis induction/exacerbation; stomatitis; hypertension, palpitation; insomnia, somnolence.

Precautions

Information Not Available

Special Precautions

Active infections; asthma; allergic disorders; haemorrhagic disorders; hypertension; impaired renal, hepatic, cardiac function.

Other Drug Interactions

Increased lornoxicam blood conc when given concomitantly with cimetidine.Enhanced effects of anticoagulants, sulfonylureas, methotrexate, ciclosporin, digoxin. Decreased effects of diuretics, ACE inhibitors.

Potentially Fatal: Increased risk of lithium toxicity.

Other Interactions

Information Not Available

Dosage

Oral
Pain relief
Adult: 8-16 mg daily. Max: 24 mg daily.

Oral
Osteoarthritis
Adult: 12 mg daily in 2-3 divided doses, up to 16 mg daily if needed.

Oral

Rheumatoid arthritis
Adult: 12 mg daily in 2-3 divided doses, up to 16 mg daily if needed.

Parenteral

Pain relief
Adult: 8 mg once or twice daily by IM/IV inj. Max: 24 mg daily.

Food(before/after)

Information Not Available

List of Contraindications

Lornoxicam and Pregnancy

Contraindicated in pregnancy

Lornoxicam and Lactation

Contraindicated in lactation

Lornoxicam and Children

Information Not Available

Lornoxicam and Geriatic

Information Not Available

Lornoxicam and Other Contraindications

Patients with peptic ulceration; severe renal impairment; pregnancy and lactation.

Storage

Information Not Available

Lab interference

Information Not Available

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