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Loratadine information from DrugsUpdate  

See Available Brands of Loratadine in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation
LI - Lab *

Loratadine is an antihistamine drug used to treat allergies, and marketed for its non-sedating properties. It is marketed by Schering-Plough and Shionogi in Japan under several trade names such as Claritin, Claritin-D, Claritine, Clarityn, Clarityne or Fristamin depending on the market; by Cadila as Lorfast; by Lek as Lomilan or Flonidan; by Sandoz as Symphoral; by Ranbaxy as Roletra; by Pliva as Rinolan; by Teva as AllergyX; by Wyeth as Alavert; and by Pharma International as Tidilor. It is also available as a generic. In a version marketed as Claritin-D or Clarinase, loratadine is combined with pseudoephedrine, a decongestant; this makes it somewhat useful for colds as well as allergies, but adds potential side-effects of insomnia, nervousness, and anxiety.

It is considered a second generation agent.

Pharmacodynamics

Pharmacokinetics

Loratadine is a non-sedating antihistamine. It works by selectively binding to peripheral histamine H1 -receptors on effector cells.

Absorption

Absorbed rapidly from the GI tract (oral); peak plasma concentrations after 1 hour. Absorption delayed by the presence of food.

Distribution

Enters breast milk, does not cross the blood-brain barrier. Protein-binding: 98%.

Metabolism

Extensively hepatic; converted to descarboethoxyloratadine (desloratadine).

Excretion

Via urine and faeces (as metabolites);elimination half-life 8.4 hours (loratadine) and 28 hours (desloratadine).

Loratadine Indications / Loratadine Uses

Information Not Available

Loratadine Adverse Reactions / Loratadine Side Effects

Fatigue, giddiness, dizziness, dry mouth, headache, nausea, somnolence.

Precautions

Information Not Available

Special Precautions

Severe hepatic damage, epilepsy, renal insufficiency

Other Drug Interactions

lasma concentrations increased by ketoconazole, cimetidine, nefazodone, erythromycin and possibly other inhibitors of CYP3A4.

Other Interactions

Information Not Available

Dosage

Oral
Allergic conditions
Adult: 10 mg once daily.
Child: 2-5 years: 5 mg once daily. 6-12 years: 10 mg once daily.


Renal impairment: Dosage may need to be reduced to alternate day admin.
Hepatic impairment: Dosage may need to be reduced to alternate day admin.

Food(before/after)

May be taken with or without food

List of Contraindications

Loratadine and Pregnancy

Contraindicated in pregnancy

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Loratadine and Lactation

Contraindicated in lactation

Loratadine and Children

Safety and efficacy not established in children younger than 6 years of age (tablets) or younger than 2 years of age (syrup).

Loratadine and Geriatic

Information Not Available

Loratadine and Other Contraindications

Pregnancy, lactation, children <2 years

Storage

Information Not Available

Lab interference

Information Not Available

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