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Lomefloxacin information from DrugsUpdate  

See Available Brands of Lomefloxacin in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Information Not Available

Pharmacodynamics

Pharmacokinetics

Lomefloxacin promotes breakage of double-stranded DNA in susceptible organisms and inhibits DNA gyrase, which is essential in reproduction of bacterial DNA.

Absorption
Rapid and complete from the GI tract (oral); peak plasma concentrations after 1-1.5 hours. Absorption delayed with food.

Distribution

Widely distributed; lungs and prostate. Protein-binding: 10%.

Excretion

Via urine (as unchanged drug and small amounts of glucuronide metabolites); may be prolonged in renal impairment. Via faeces (small amounts as unchanged drug); 7-8 hours (elimination half-life).

Lomefloxacin Indications / Lomefloxacin Uses

Information Not Available

Lomefloxacin Adverse Reactions / Lomefloxacin Side Effects

Nausea, abdominal pain or discomfort, diarrhoea; headache, dizziness, insomnia; rash, pruritus, photosensitivity; thrombocytopenia.

Potentially Fatal: Anaphylactic or anaphylactoid reactions.

Precautions

Information Not Available

Special Precautions

Avoid prolonged exposure to sunlight or artificial UV light. Known or suspected CNS disorders e.g. severe cerebral arteriosclerosis, epilepsy or other factors that predispose to seizures. Avoid in patients with known QT prolongation, uncorrected hypokalaemia. May impair ability to drive or operate machinery. Renal impairment.

Other Drug Interactions

Reduced bioavailability with sucralfate, antacids containing magnesium or aluminium, vitamin or mineral supplements containing iron. Increased serum levels with cimetidine. Potential increase in serum levels of ciclosporin. Renal elimination reduced with probenecid.

Potentially Fatal: Increased risk of ventricular arrhythmias with class IA (quinidine, procainamide) or class III (amiodarone, sotalol) antiarrhythmic agents.

Other Interactions

Information Not Available

Dosage

Oral
Acute bacterial exacerbation of chronic bronchitis
Adult: 400 mg once daily for 10 days.
Renal impairment: Haemodialysis: Initially, 400 mg daily. Maintenance: 200 mg daily.
CrCl (ml/min)    Dosage Recommendation
10-40               Initially, 400 mg daily. Maintenance: 200 mg daily.

Oral

Prophylaxis of surgical infections
Adult: 400 mg as a single dose 1-6 hr before procedure.
 Uncomplicated urinary tract infections
Adult: 400 mg once daily. Due to E. coli: For 3 successive days. Due to K. pneumoniae, P. mirabilis or S. saprophyticus: For 10 successive days.
Renal impairment: Haemodialysis: Initially, 400 mg daily. Maintenance: 200 mg daily.
CrCl (ml/min)    Dosage Recommendation
10-40               Initially, 400 mg daily. Maintenance: 200 mg daily.

Oral
Complicated urinary tract infections
Adult: Due to E. coli, K. pneumoniae, P. mirabilis or P. aeruginosa: 400 mg once daily for 14 successive days.
Renal impairment: Haemodialysis: Initially, 400 mg daily. Maintenance: 200 mg daily.
CrCl (ml/min)    Dosage Recommendation
10-40               Initially, 400 mg daily. Maintenance: 200 mg daily.

Ophthalmic
Bacterial conjunctivitis
Adult: Instil 0.3% solution into the affected eye/s.

Otic/Aural
Otitis externa
Adult: Instil 0.3% solution into the affected ear/s.

Otic/Aural
Otitis media
Adult: Instil 0.3% solution into the affected ear/s.

Food(before/after)

May be taken with or without food.

List of Contraindications

Lomefloxacin and Pregnancy

Contraindicated in pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Lomefloxacin and Lactation

Contraindicated in lactation

Lomefloxacin and Children

Information Not Available

Lomefloxacin and Geriatic

Information Not Available

Lomefloxacin and Other Contraindications

Hypersensitivity to the drug or other quinolones; children <18 years; pregnancy and lactation.

Storage

Information Not Available

Lab interference

Information Not Available

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