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Levocetirizine information from DrugsUpdate  

See Available Brands of Levocetirizine in India

L - Contraindicated in lactation

Levocetirizine (as levocetirizine dihydrochloride) is a third-generation non-sedative antihistamine, developed from the second-generation antihistamine cetirizine. Chemically, levocetirizine is the active enantiomer of cetirizine. It is the L-enantiomer of the cetirizine racemate. Levocetirizine works by blocking histamine receptors. It does not prevent the actual release of histamine from mast cells, but prevents it binding to its receptors. This in turn prevents the release of other allergy chemicals and increased blood supply to the area, and provides relief from the typical symptoms of hayfever.

Pharmacodynamics

Pharmacokinetics

Levocetirizine, an active isomer of cetirizine, selectively inhibits histamine H1-receptors.

Absorption

Rapidly and extensively absorbed from the GI tract (oral); peak plasma concentration in 0.9 hours.

Distribution
Protein-binding: 91-92%.

Metabolism

Via aromatic oxidation, N- and O-dealkylation and taurine conjugation.

Excretion

Via urine (85.4%), via faeces (12.9%), as metabolites and unchanged drug; 8 hours (plasma half-life).

Levocetirizine Indications / Levocetirizine Uses

Information Not Available

Levocetirizine Adverse Reactions / Levocetirizine Side Effects

Fatigue, somnolence, dry mouth, nasopharyngitis, pyrexia, cough, epistaxis.

Precautions

Information Not Available

Special Precautions

Renal impairment. May impair ability to drive or operate machinery.

Other Drug Interactions

Additive sedation with alcohol and other CNS depressants.

Other Interactions

Information Not Available

Dosage

Oral
Allergic conditions
Adult: As hydrochloride: 5 mg daily in the evening; 2.5 mg may be adequate in some patients. Max dose: 5 mg daily.
Child: As hydrochloride: 6-11 years: 2.5 mg once daily. Max dose: 2.5 mg daily. ≥12 years: 5 mg once daily; 2.5 mg may be adequate is some patients. Max dose: 5 mg daily. All doses to be taken in the evening.
CrCl (ml/min)    Dosage Recommendation
50-80        2.5 mg once daily.
30-50        2.5 mg every other day.
10-30        2.5 mg twice weekly (give every 3-4 days).

Food(before/after)

May be taken with or without food.

List of Contraindications

Levocetirizine and Pregnancy

Information Not Available

Levocetirizine and Lactation

Contraindicated in lactation

Levocetirizine and Children

Information Not Available

Levocetirizine and Geriatic

Information Not Available

Levocetirizine and Other Contraindications

Lactation. End-stage renal disease (CrCl <10 ml/min) or haemodialysis patients. Child 6-11 years with renal impairment.

Storage

Oral
Store at 20-25°C (68-77°F).

Lab interference

Oral
Store at 20-25°C (68-77°F).

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