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Levobunolol information from DrugsUpdate  

See Available Brands of Levobunolol in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Levobunolol (AK-Beta, Liquifilm, Betegan) is a non-selective beta blocker. It is used topically to manage glaucoma.



Levobunolol, a nonselective β-adrenergic blocking agent, decreases IOP by reducing aqueous humour production.

Within 1 hour (ophthalmic).

Up to 24 hours (ophthalmic).

Rapidly and almost completely absorbed from the GI tract (oral).

Extensively hepatic.

Via urine as metabolites and unchanged drug.

Levobunolol Indications / Levobunolol Uses

Information Not Available

Levobunolol Adverse Reactions / Levobunolol Side Effects

Ocular stinging, burning, blepharoconjunctivitis, decreased heart rate, decreased BP, iridocyclitis, headache, transient ataxia, dizziness, lethargy, decreased corneal sensitivity, tearing, visual disturbances, urticaria and pruritus.


Levobunolol HCl ophthalmic solution USP sterile should be used with caution in patients with known hypersensitivity to other beta-adrenoceptor blocking agents.Use with caution in patients with known diminished pulmonary function.

Levobunolol HCl ophthalmic solution should be used with caution in patients who are receiving a beta-adrenergic blocking agent orally, because of the potential for additive effects on systemic beta-blockade or on intraocular pressure. Patients should not typically use two or more topical ophthalmic beta-adrenergic blocking agents simultaneously.

Because of the potential effects of beta-adrenergic blocking agents on blood pressure and pulse rates, these medications must be used cautiously in patients with cerebrovascular insufficiency. Should signs or symptoms develop that suggest reduced cerebral blood flow while using Levobunolol HCl ophthalmic solution, alternative therapy should be considered.

In patients with angle-closure glaucoma, the immediate objective of treatment is to reopen the angle. This requires, in most cases, constricting the pupil with a miotic. Levobunolol HCl ophthalmic solution has little or no effect on the pupil. When Levobunolol HCl is used to reduce elevated intraocular pressure in angle-closure glaucoma, it should be followed with a miotic and not alone.

Muscle Weakness: Beta-adrenergic blockade has been reported to potentiate muscle weakness consistent with certain myasthenic symptoms (e.g., diplopia, ptosis and generalized weakness).

Special Precautions

Patients at risk of developing hypoglycaemia. DM. Thyrotoxicosis. Known diminished pulmonary function. Cerebrovascular insufficiency. Do not drive or operate machinery until vision is clear. Pregnancy and lactation.

Other Drug Interactions

Mydriasis may occur when used with epinephrine. Additive effects with catecholamine-depleting drugs e.g. reserpine. Possible AV conduction disturbances, LVF and hypotension with IV calcium antagonists. Additive prolongation of AV conduction time with digitalis and calcium antagonists. Additive hypotensive effects with phenothiazine-related agents. Additive effect with systemic β-blockers.

Other Interactions

Information Not Available


Open-angle glaucoma, Ocular hypertension
Adult: As hydrochloride: 0.5% solution: 1-2 drops of in the affected eye(s) once daily; may be given bid for more severe or uncontrolled glaucoma. 0.25% solution: 1-2 drops bid.


Information Not Available

List of Contraindications

Levobunolol and Pregnancy

Caution when used during pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Levobunolol and Lactation

Caution when used during lactation

Levobunolol and Children

Safety and efficacy not established

Levobunolol and Geriatic

No overall differences in safety or effectiveness have been observed between elderly and younger patients.

Levobunolol and Other Contraindications

Bronchial asthma, severe COPD; sinus bradycardia; 2nd and 3rd degree heart block; overt cardiac failure; cardiogenic shock.


Store at 15-30°C (59-86°F).

Lab interference

Store at 15-30°C (59-86°F).

Levobunolol brands in India:


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