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Levamisole information from DrugsUpdate  

See Available Brands of Levamisole in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Levamisole (marketed as the hydrochloride salt under the trade name Ergamisol) is an antibiotic belonging to a class of synthetic imidazothiazole derivatives. It was discovered at Janssen Pharmaceutica in 1966.

Ergamisol was withdrawn from the U.S. and Canadian markets, in 2000 and 2003 respectively, due to occurence of serious side effects in some people in the face of availability of replacement pharmaceuticals.

Pharmacodynamics

Pharmacokinetics

Levamisole is the active laevo-isomer of tetramisole. It works by paralysing susceptible intestinal worms which are then excreted from the intestines. Levamisole also enhances cellular immune responses in humans.

Absorption
Well-absorbed from the GI tract. Peak plasma concentrations are achieved in 1.5-2 hours.

Metabolism
Occurs extensively in the liver.

Excretion

Mainly in the urine (70% as metabolites and 5% as unchanged drug) and small amounts in the faeces.

Levamisole Indications / Levamisole Uses

Information Not Available

Levamisole Adverse Reactions / Levamisole Side Effects

Nausea, vomiting, diarrhoea, abdominal pain, dizziness and headache. Fever, influenza-like syndrome, arthralgia, muscle pain, rash, taste disturbances and cutaneous vasculitis.

Potentially Fatal: Agranulocytosis, leucopenia, thrombocytopenia.

Precautions

Information Not Available

Special Precautions

Hepatic impairment, Sjogren's syndrome.

Other Drug Interactions

May increase toxicity of phenytoin. Increases bioavailability of ivermectin; decreases bioavailability of albendazole. Alcohol causes disulfiram-like reaction.

Other Interactions

Information Not Available

Dosage

Oral
Ascariasis
Adult: 150 mg as a single dose.
Child: 3 mg/kg as a single dose.

Oral

Ancylostomiasis
Adult: 2.5 mg/kg as a single dose, repeated after 7 days in severe cases.
Child: 2.5 mg/kg as a single dose, repeated after 7 days in severe cases.

Oral
Mixed ascariasis hookworm infections
Adult: 2.5 mg/kg as a single dose, repeated after 7 days in severe cases.
Child: 2.5 mg/kg as a single dose, repeated after 7 days in severe cases.

Food(before/after)

Should be taken with food. (Take w/ meals to minimise side effects such as nausea.)

List of Contraindications

Levamisole and Pregnancy

Contraindicated in pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Levamisole and Lactation

Contraindicated in lactation

Levamisole and Children

Information Not Available

Levamisole and Geriatic

Information Not Available

Levamisole and Other Contraindications

Preexisting blood disorders; pregnancy and lactation; rheumatoid arthritis; severe renal impairment.

Storage

Information Not Available

Lab interference

Information Not Available

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