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Ketotifen information from DrugsUpdate  

See Available Brands of Ketotifen in India

P - Contraindicated in pregnancy
L - Contraindicated in Lactation

Ketotifen is used to minimize the frequency and severity of asthma attacks. This medication may allow for a reduction in the use of other asthma medications. Ketotifen is not effective in treating an active asthma attack (acute attack).

Ketotifen relieves and prevents eye itchiness and/or irritation associated with most seasonal allergies. It starts working within minutes after administering the drops. The drug has not been studied in children under 3. The mean elimination half life is 12 hours.

Besides its anti-histaminic activity, it is also a functional leukotriene antagonist and a phosphodiesterase inhibitor.

Pharmacodynamics

Pharmacokinetics

Ketorolac inhibits prostaglandin synthesis by decreasing the activity of the cyclooxygenase enzyme.

Onset

30-60 minutes (oral); 10 minutes (IM).

Duration
6-8 hours (oral/IM).

Absorption
Well absorbed (oral/IM); peak plasma concentrations after 30-60 minutes

Distribution
Protein-binding: 99%. Crosses the placenta; enters breast milk; poorly penetrates into CSF.

Metabolism
Hepatic via glucuronic acid conjugation.

Excretion
Via urine (90%, as unchanged drug and metabolites); via faeces (remaining dose). Terminal elimination half-life: 4-6 hours; 6-7 hours (elderly); 9-10 hours (renal impairment).

Ketotifen Indications / Ketotifen Uses

Information Not Available

Ketotifen Adverse Reactions / Ketotifen Side Effects

GI ulcer, bleeding and perforation, drowsiness, rash, bronchospasm, hypotension, psychosis, dry mouth, fever, bradycardia, chest pain, dizziness, headache, sweating, oedema, pallor, liver function changes. Transient stinging and local irritation (ophthalmic).

Potentially Fatal: Anaphylaxis. Severe skin reactions. MI, stroke, GI bleeding.

Precautions

Information Not Available

Special Precautions

Elderly, patients weighing <50 kg, hepatic dysfunction, heart failure, predisposition to reduced blood volume or renal blood flow. Mild renal impairment; monitor renal function closely.

Other Drug Interactions

May reduce effects of antihypertensives (e.g. ACE inhibitors or angiotensin II receptor antagonists). Increased risk of renal toxicity with ACE inhibitors, diuretics. Increased adverse effects with aspirin or other NSAIDs. Hallucinations may occur when used with fluoxetine, thiothixene, alprazolam.

Potentially Fatal: Increased risk of GI bleeding with warfarin. May increase toxicity of methotrexate and lithium. Increased plasma concentrations with probenecid.

Other Interactions

Information Not Available

Dosage

Oral
Moderate to severe pain
Adult: 10 mg every 4-6 hours. Max: 40 mg/day. Max duration: 7 days.
Elderly: 10 mg every 6-8 hours. Max duration: 7 days.

Renal impairment: Contraindicated in moderate to severe impairment.

Parenteral
Moderate to severe pain
Adult: 60 mg as a single dose via IM injection or 30 mg as a single IV dose. Alternatively, 30 mg every 6 hours via IM or IV admin up to a max of 120 mg daily. Halve the doses in patients weighing <50 kg. Max duration: 2 days; patient should be transferred to oral therapy as soon as possible.
Elderly: 30 mg as a single dose via IM injection or 15 mg as a single IV dose. Alternatively, 15 mg every 6 hours via IM or IV admin up to a max of 60 mg daily.

Renal impairment: 30 mg as a single dose via IM injection or 15 mg as a single IV dose. Alternatively, 15 mg every 6 hours via IM or IV admin up to a max of 60 mg daily. Contraindicated in moderate to severe impairment.

Ophthalmic
Ocular itching associated with seasonal allergic conjunctivitis
Adult: As trometamol: Instil 1 drop of a 0.5% solution into the affected eye(s) 4 times daily.

Renal impairment: Contraindicated in moderate to severe impairment.

Ophthalmic
Prophylaxis and reduction of postoperative ocular inflammation
Adult: As trometamol: Instil 1 drop of a 0.5% solution into the appropriate eye(s) 4 times daily starting 24 hours after surgery. Continue for 2 weeks

Renal impairment: Contraindicated in moderate to severe impairment.

Ophthalmic

Cystoid macular oedema
Adult: As trometamol: Instil 1-2 drops of a 0.5% solution into the appropriate eye(s) every 6-8 hours starting 24 hours before surgery and continue for 3-4 weeks after surgery.

Renal impairment: Contraindicated in moderate to severe impairment.

Ophthalmic
Pain and photophobia after incisional refractive surgery
Adult: As trometamol: Instil 1 drop of a 0.5% solution 4 times daily into the operated eye for up to 3 days after surgery.
Renal impairment: Contraindicated in moderate to severe impairment.

Incompatibility
Y-site incompatibility: Fenoldopam, azithromycin. Syringe incompatibility: Promethazine, hydroxyzine, nalbuphine, haloperidol, prochorperazine edisylate, triethylperazine. Admixture incompatibility: Promethazine, morphine, hydroxyzine, meperidine.

Food(before/after)

Information Not Available

List of Contraindications

Ketotifen and Pregnancy

Contraindicated in pregnancy

Ketotifen and Lactation

Contraindicated in lactation

Ketotifen and Children

Safety and efficacy not established in children younger than 3 years of age.

Ketotifen and Geriatic

Information Not Available

Ketotifen and Other Contraindications

Hypersensitivity to aspirin or other NSAIDs, asthma. Hypovolaemia or dehydration. Do not give postoperatively to patients with high risk of haemorrhage. History of peptic ulcer or coagulation disorders. Nasal polyps, angioedema, bronchospasm. Labour. Moderate to severe renal impairment. GI bleeding, cerebrovascular bleeding. As prophylactic analgesic before surgery. Pregnancy, lactation.

Storage

Ophthalmic
Store at 15-25°C (59-77°F).

Oral

Store at 15-30°C (59-86°F).

Parenteral

Store at 15-30°C (59-86°F). Protect from light.

Lab interference

Ophthalmic
Store at 15-25°C (59-77°F).

Oral

Store at 15-30°C (59-86°F).

Parenteral

Store at 15-30°C (59-86°F). Protect from light.

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