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Ivermectin information from DrugsUpdate  

See Available Brands of Ivermectin in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation
FI - Food *

Ivermectin (22,23-dihydroavermectin B1a + 22,23-dihydroavermectin B1b) is a broad-spectrum antiparasitic medication.

It is sold under brand names Stromectol in the United States, Mectizan in Canada by Merck and Ivexterm in Mexico by Valeant Pharmaceuticals International.

Pharmacodynamics

Ivermectin and other avermectins (insecticides most frequently used in home-use ant baits) are macrocyclic lactones derived from the bacterium Streptomyces avermitilis. Ivermectin kills by interfering with nervous system and muscle function, in particular by enhancing inhibitory neurotransmission.

The drug binds and activates glutamate-gated chloride channels (GluCls)[12]. GluCls are invertebrate-specific members of the Cys-loop family of ligand-gated ion channels present in neurons and myocytes.

Pharmacokinetics

Information Not Available

Ivermectin Indications / Ivermectin Uses

Information Not Available

Ivermectin Adverse Reactions / Ivermectin Side Effects

Diarrhoea, nausea, vomiting, dizziness, pruritus, utricaria, rash, arthralgia, fever, myalgia, asthenia, postural hypotension, tachycardia, oedema, lymphadenopathy, sore throat, cough, heahache, somnolence, transient eosinophilia, raised liver enzyme values.

Precautions

Information Not Available

Special Precautions

Concurrent Loa Loa infection, imapired blood- brain barrier function due to infection

Other Drug Interactions

Bioavailability may be increased by alcohol, levamisole

Other Interactions

Food Interaction

Dosage

Oral
Onchocerciasis
Adult ≥15kg: 150 mcg/kg as a single dose for every 6- 12 months until asymptomatic;
Child > 5 years & ≥15kg: 150mcg/kg as a single dose every 6- 12 months until asymptomatic.

Strongyloidiasis

Adult ≥15kg: 200 mcg/kg once daily for 1-2 days. For immunocompromised patients: May need to repeat every 2-4 weeks.
Child: > 15kg: 200 mcg/kg as a single dose or daily on two consecutive days. For immunocompromised patients: May need to repeat dose every 2-4 weeks.

Food(before/after)

Information Not Available

List of Contraindications

Ivermectin and Pregnancy

Contraindicated in pregnancy

Ivermectin and Lactation

Contraindicated in lactation

Ivermectin and Children

Information Not Available

Ivermectin and Geriatic

Information Not Available

Ivermectin and Other Contraindications

Hypersensitivity. Pregnancy & lactation. Children < 15kg body weight. <!-- @page { margin: 0.79in } P { margin-bottom: 0.08in } -->


 


 

Storage

Information Not Available

Lab interference

Information Not Available

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