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Iron Polymaltose information from DrugsUpdate  

See Available Brands of Iron Polymaltose in India

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Pharmacodynamics

Pharmacokinetics

Iron polymaltose is a water soluble, macro-molecular complex of iron (III) hydroxide and isomaltose. It is used in the treatment of iron-deficiency anaemia.

Iron Polymaltose Indications / Iron Polymaltose Uses

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Iron Polymaltose Adverse Reactions / Iron Polymaltose Side Effects

GI irritation, epigastric pain, stomach cramping, constipation, nausea, vomiting, diarrhoea, dark stools, heart burn, discoloured urine, teeth staining. IM: pain at inj site, abdominal pain at lower quadrant and local inflammation with inguinal lymphadenopathy. IV: Joint and muscle pain, bronchospasm, hypotension, tachycardia, flushing, sweating, dizziness.

Potentially Fatal: Parenteral: Anaphylactoid reactions, circulatory collapse.

Precautions

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Special Precautions

Avoid concomitant parenteral and oral iron admin, oral iron therapy should start at least 1 week after last iron injection. Parenteral: Pregnancy (2nd and 3rd trimester), allergies, hepatic and liver insufficiency, low iron binding capacity and or folic acid deficiency. Facilities for CPR should be available during admin. Excessive IV infusion rate may cause nausea and epigastric upset. IV infusion route should be used only if IM route is unacceptable and when there is no stored iron in the bone marrow.

Other Drug Interactions

Concurrent use with psychotropic drugs may worsen constipation. Increased systemic side effects with concomitant ACE inhibitors and parenteral iron admin.

Other Interactions

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Dosage

Oral
Iron-deficiency anaemia
Adult: As chewable tablet/syrup/drops: Doses equivalent to 100 mg of elemental iron daily, up to 300 mg daily.

Intravenous
Iron-deficiency anaemia
Adult: As injection containing 100 mg iron as iron polymaltose/2 ml: Total dose of iron needed (mg): Wt (kg) x (normal haemoglobin - actual haemoglobin in g/L) x 0.24 + iron depot. Iron depot calculated as 15 mg/kg up to a wt of about 34 kg, max of 500 mg for body wt ≥ 34 kg. Refer to product insert for dosage table. 1st 50 ml to be infused slowly (5-10 drops/minute) and observe patient closely. If well tolerated, increase rate to 30 drops/minute (based on drop volume of 0.067ml).
Child: As injection containing 100 mg iron as iron polymaltose/2 ml: Total dose of iron needed (mg): Wt (kg) x (normal haemoglobin - actual haemoglobin in g/L) x 0.24 + iron depot. Iron depot calculated as 15 mg/kg up to a wt of about 34 kg, max of 500 mg for body wt ≥ 34 kg. Refer to product insert for dosage table. 1st 50 ml to be infused slowly (5-10 drops/minute) and observe patient closely. If well tolerated, increase rate to 30 drops/minute (based on drop volume of 0.067ml).

Intramuscular
Iron-deficiency anaemia
Adult: As injection containing 100 mg iron as iron polymaltose/2 ml: Admin by ventro-gluteal inj according to Hochstetter method (refer to package insert for details). Total dose of iron needed (mg): Wt (kg) x (normal haemoglobin - actual haemoglobin in g/L) x 0.24 + iron depot. Iron depot calculated as 15 mg/kg up to a wt of about 34 kg, max of 500 mg for body wt ≥34 kg. May give dose as alternate day inj of 2 ml (or 4 ml at longer interval) until total dose is reached. Max single daily dose: >10-45 kg: 2 ml; >45 kg: 4 ml.
Child: As inj containing 100 mg iron as iron polymaltose/2 ml: Admin by ventro-gluteal inj according to Hochstetter method (refer to package insert for details).Total dose of iron needed (mg): Wt (kg) x (normal haemoglobin - actual haemoglobin in g/L) x 0.24 + iron depot. Iron depot calculated as 15 mg/kg up to a wt of about 34 kg, max of 500 mg for body wt ≥ 34 kg. Max single daily dose: >10-45 kg: 2 ml; 5-10 kg: 1 ml; infants (up to 5 kg): 0.5 ml.

Reconstitution
IV infusion: Total dose to be admin to be added to 500 ml of normal saline (max 2500 mg in 500 ml).

Incompatibility
Do not mix with acidic substance or substances with a strong reducing effect.

Food(before/after)

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List of Contraindications

Iron Polymaltose and Pregnancy

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Iron Polymaltose and Lactation

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Iron Polymaltose and Children

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Iron Polymaltose and Geriatic

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Iron Polymaltose and Other Contraindications

Hypersensitivity or intolerance to iron and overloading of iron in the body. Anaemia not caused by iron deficiency. Disturbances in iron utilisation, thalassemia. Patients receiving repeated blood transfusion. Parenteral: Iron overload, Ostler-Rendu-Weber syndrome, chronic polyarthritis, bronchial asthma, inflammation or infection of kidney or liver, uncontrolled hyperparathyroidism, decompensated liver cirrhosis. Pregnancy (1st trimester).

Storage

Intramuscular
Store below 25°C. Do not freeze
Intravenous
Store below 25°C. Do not freeze

Oral
Store below 25°C.

Lab interference

Intramuscular
Store below 25°C. Do not freeze
Intravenous
Store below 25°C. Do not freeze

Oral
Store below 25°C.

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