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Hyaluronidase information from DrugsUpdate  

See Available Brands of Hyaluronidase in India

P - Caution when used during pregnancy
L - Caution when used during lactation

The hyaluronidases (EC 3.2.1.35) are a family of enzymes that degrade hyaluronic acid.

In humans, there are six associated genes, including HYAL1, HYAL2, HYAL3, and PH-20/SPAM1.

Pharmacodynamics

Pharmacokinetics

Hyaluronidase is an enzyme which reduces the viscosity of ground substance, thus making the tissues more permeable to injected fluids. It facilitates distribution and absorption of locally injected substances. It also promotes resorption of excess fluids and extravasated blood in the tissues.

Hyaluronidase Indications / Hyaluronidase Uses

Information Not Available

Hyaluronidase Adverse Reactions / Hyaluronidase Side Effects

Urticaria, occasional severe allergy.

Potentially Fatal: Hypersensitivity and anaphylaxis.

Precautions

Monitor
Injection-site reaction
Monitor patient for reactions at injection site and for adverse reactions commonly associated with any drug coadministered with hyaluronidase.

Special Precautions

Impaired renal function. Infants, elderly. Patients with infections. Pregnancy, lactation.

Other Drug Interactions

Action potentiated by urokinase especially in the treatment of MI. May increase absorption and toxicity of local anaesthetics. Heparin, salicylates and NSAIDs may inhibit the spreading action and efficacy of hyaluronidase.

Other Interactions

Information Not Available

Dosage

Parenteral
Adjunct in hypodermoclysis
Adult: 1500 units for every 500-1000 ml of fluid for SC admin.

Parenteral
Facilitate SC/IM injections
Adult: 1500 units directly added to the inj.

Parenteral
Aid in the dispersal of extravasated fluids or blood
Adult: 1500 units in 1 ml of water for inj or normal saline is injected into the affected area.

Parenteral
Aid in the diffusion of local anaesthetic in ophthalmology
Adult: 15 units/ml of local anaesthetic solution.

Incompatibility
Physical incompatibility has been reported with heparin and adrenaline, frusemide, benzodiazepines and phenytoin.

Food(before/after)

Information Not Available

List of Contraindications

Hyaluronidase and Pregnancy

Caution when used during pregnancy

Hyaluronidase and Lactation

Caution when used during lactation

Hyaluronidase and Children

Information Not Available

Hyaluronidase and Geriatic

Information Not Available

Hyaluronidase and Other Contraindications

Hypersensitivity, malignancy. Direct application to the cornea, reduction of swelling of bites or stings. Inj into or around infected area. IV admin; unexplained premature labour.

Storage

Parenteral
Refrigerate at 2-8°C

Lab interference

Parenteral
Refrigerate at 2-8°C

Hyaluronidase brands in India:

Facidase Facidase INJ Hylorase Hynidase Spreadase

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