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Gliclazide information from DrugsUpdate  

See Available Brands of Gliclazide in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Gliclazide is an oral hypoglycemic (anti-diabetic drug) and is classified as a sulfonylurea. It is marketed as Diamicron and Dianorm in India. The modified-release formulation of Diamicron is marketed as Remicron MR, Diabeton MR, Diamicron 30mg, Diamicron LM 30mg, Diamicron MR 30 mg, Diamicron Uno 30mg, Dianormax MR, Diaprel MR and Uni Diamicron.

Its classification has been ambiguous as literature uses it as both a first-generation and second-generation sulfonylurea.



Gliclazide stimulates insulin secretion from pancreatic β-cells, reduces hepatic gluconeogenesis, and lowers blood glucose concentrations. It also inhibits platelet aggregation at therapeutic doses.

≥12 hours.

Readily absorbed from the GI tract (oral).

Protein-binding: 94%.


Extensively hepatic; converted to inactive metabolites.


Urine (60-70% metabolites and small amounts of unchanged drug); faeces (10-20%); 10-12 hours (elimination half-life).

Gliclazide Indications / Gliclazide Uses

Information Not Available

Gliclazide Adverse Reactions / Gliclazide Side Effects

GI disturbances, skin reaction, leucopenia, thrombocytopenia, agranulocytosis, haemolytic anaemia, cholestatic jaundice, vomiting, diarrhoea, gastritis, increased transaminases.


Information Not Available

Special Precautions

Monitor blood glucose concentration. May require insulin during metabolic stress. Care when transferring from combination therapy. Increased risk of severe hypoglycaemia in elderly, debilitated patients, patients with hepatic or renal impairment. Risk of hypogylcaemia when caloric intake is deficient, after strenuous exercise, when taken with ethanol or when >1 antidiabetic drug is used.

Other Drug Interactions

Nausea and flushing with alcohol. Hypoglycaemic effect increased by salicylates, phenylbutazone, clofibrate, sulphonamides, oral anticoagulants and MAOIs. Hypoglycaemic effect diminished by rifampicin, barbiturates, alcohol, diuretics, diazoxide, corticosteroids, β-blockers, oestrogens and sympathomimetic drugs; dose adjustment may be required.

Other Interactions

Information Not Available


Type 2 diabetes mellitus
Adult: Initially, 40-80 mg daily gradually increased to 320 mg daily if necessary. Doses >160 mg daily may be given in 2 divided doses. For modified release tab: Initially, 30 mg once daily, may increase up to 120 mg daily.


Should be taken with food

List of Contraindications

Gliclazide and Pregnancy

Contraindicated in pregnancy

Gliclazide and Lactation

Contraindicated in lactation

Gliclazide and Children

Information Not Available

Gliclazide and Geriatic

Information Not Available

Gliclazide and Other Contraindications

Type 1 DM, diabetes complicated with ketoacidosis; hypersensitivity; severe renal and hepatic impairment. Pregnancy and lactation.


Information Not Available

Lab interference

Information Not Available

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