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Auranofin information from DrugsUpdate  

See Available Brands of Auranofin in India

P - Caution when used during pregnancy
L - Contraindicated in lactation

Ridaura, a gold preparation, is given to help treat rheumatoid arthritis. Ridaura is taken by mouth, unlike other gold compounds, which are given by injection.

It is recommended only for people who have not been helped sufficiently by nonsteroidal anti-inflammatory drugs (Anaprox, Dolobid, Indocin, ibuprofen, and others). Ridaura should be part of a comprehensive arthritis treatment program that includes non-drug forms of therapy.



Auranofin is a gold compound that exhibits anti-inflammatory and antiarthritic effects. It is taken up by macrophages, resulting in inhibition of phagocytosis and lysosomal membrane stabilisation. It also reduces serum rheumatoid factor, lysosomal enzyme activity and complement activation; and inhibits prostaglandin synthesis.

Only about 25% absorbed from the GI tract (oral); steady-state conc in blood is 0.7 mcg/mL.

Penetrates into synovial fluid; bound to plasma proteins and RBCs.

Majority of a dose is removed in faeces. 60% of absorbed dose is removed in urine and the remainder in faeces; about 26 days (elimination half-life).

Auranofin Indications / Auranofin Uses

Information Not Available

Auranofin Adverse Reactions / Auranofin Side Effects

GI disturbances (nausea, vomiting, abdominal pain, diarrhoea), pruritus, rash; dermatitis, lesions of mucous membranes, ulcerative enterocolitis, haemotological disorders (including aplastic anaemia), proteinuria, nephrotic syndrome, alopoecia, conjunctivitis, metallic taste, blood dyscrasias, pulmonary fibrosis, psychosis; stomatitis, haematuria.

Potentially Fatal: Agranulocytosis, thrombocytopenia, toxic hepatitis, encephalitis.


Lab values
Review laboratory values for indications of gold toxicity such as decreased hemoglobin, less than 4,000WBC/mm 3 , platelets less than 100,000 to 150,000/cu mm, proteinuria, and elevated liver enzymes.

Observe patient for early symptoms of toxicity such as a metallic taste in the mouth, pruritus or rash.

Special Precautions

Chronic cardiac failure, history of allergies; elderly. Monitor urine and blood tests before starting therapy and mthly thereafter. Withdraw treatment when platelets drop <100 000/mm3 or if there are signs and symptoms of thrombocytopenia.
Consider alternative treatment in patients with dermatitis, history of inflammatory bowel disease, hepatic impairment. Pregnancy.

Other Drug Interactions

Possible increased risk of nitritoid reactions when used with ACE inhibitors. Increased risk of toxicity with other nephrotoxic, hepatotoxic or myelosuppressive drugs. Possible increase in phenytoin level in blood.

Other Interactions

Information Not Available


Active progressive rheumatoid arthritis
Adult: Initially, 6 mg/day in 2 divided doses, if tolerated, may be given as single dose subsequently. May increase dose to 9 mg/day in 3 divided doses if response is inadequate after 6 mth; assess response 3 mth later, discontinue if there is still no response.
CrCl (ml/min)    Dosage Recommendation
50-80               Half the normal dose.
<50                  Avoid use.


Should be taken with food (Take after meals or a light snack)

List of Contraindications

Auranofin and Pregnancy

Caution when used during pregnancy.

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Auranofin and Lactation

Contraindicated in lactation. Excreted in breast milk

Auranofin and Children

Safety and efficacy not established

Auranofin and Geriatic

Tolerance decreases with age

Auranofin and Other Contraindications

Congestive heart failure, SLE, renal dysfunction; history of blood dyscrasias, history of gold-induced anaphylactic reactions (e.g. necrotising enterocolitis, pulmonary fibrosis, exfoliative dermatitis, bone marrow aplasia). Lactation; porphyria.


Store at 15-30°C

Lab interference

Store at 15-30°C

Auranofin brands in India:


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