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Gemfibrozil information from DrugsUpdate  

See Available Brands of Gemfibrozil in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation
LI - Lab *

Gemfibrozil is the generic name for an oral drug used to lower lipid levels. It belongs to a group of drugs known as fibrates. It is most commonly sold as the brand name, Lopid. Other brand names include Jezil and Gen-Fibro.



Gemfibrozil exhibits its action by inhibition of lipolysis and reduction of hepatic fatty acid uptake. It also inhibits secretion of VLDL from the liver.

Readily absorbed from the GI tract (oral); peak plasma concentrations after 1-2 hr.

Protein-binding: 80%.

Hepatic via oxidation; undergoes enterohepatic recirculation.

Urine (70% glucuronide conjugates and metabolites); faeces (small amounts); 1.5 hr (elimination half-life).

Gemfibrozil Indications / Gemfibrozil Uses

Information Not Available

Gemfibrozil Adverse Reactions / Gemfibrozil Side Effects

Myositic syndrome, cholelithiasis, GI disturbances, rash, headache, blood dyscrasias, myalgia. Impotence, painful extremities, blurred vision; pruritus, urticaria; impotence; dizziness; cholestatic jaundice.

Potentially Fatal: Bone marrow hypoplasia; intracranial haemorrhage; nephrotoxicity; peripheral neuritis.


Information Not Available

Special Precautions

Causes of secondary hyperlipidaemia such as hypothyroidism and diabetes must be treated before initiating therapy. Renal impairment; blood disorders. Periodic monitoring of the serum lipids should be done; if no adequate response after 3 mth, treatment should be withdrawn. May increase risk of cholelithiasis.

Other Drug Interactions

Co-admin with repaglinide may increase serum levels of repaglinide. May enhance effects of oral anticoagulants. May also increase the plasma concentrations of ciclosporin and associated nephrotoxicity when used concurrently.

Potentially Fatal: Increased risk of myopathy and rhabdomyolysis when used with HMG-CoA reductase inhibitors.

Other Interactions

Information Not Available


Adult: 1.2 g daily in 2 divided doses. Maintenance: 0.9-1.5 g daily.


Should be taken on an empty stomach. (Take ½ hr before meals.)

List of Contraindications

Gemfibrozil and Pregnancy

Contraindicated in pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Gemfibrozil and Lactation

Contraindicated in lactation

Gemfibrozil and Children

Safety and efficacy not established

Gemfibrozil and Geriatic

Information Not Available

Gemfibrozil and Other Contraindications

Hypersensitivity. Severe hepatic or renal dysfunction; gall stones; neonates, children, pregnancy, lactation.


Store below 30°C.

Lab interference

Store below 30°C.

Gemfibrozil brands in India:

Gempar Lipizyl Lopid Losterol Normolip Triglyd

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