Fusidic acid disrupts translocation of peptide subunits and elongating the peptide chain of susceptible bacteria, thus inhibiting protein synthesis.

Absorption
Well-absorbed from the GI tract (oral); mean plasma concentrations of 30 mcg/ml after 2-4 hours (500-mg dose). More rapid absorption in children than in adults.

Distribution
Widely distributed into tissues and body fluids including bone, pus and synovial fluid; crosses the placenta and enters breast milk. Protein-binding: 95%.

Metabolism
Hepatic; converted to multiple metabolites.

Excretion
Bile (mainly as metabolites), faeces (2% as unchanged drug), urine; 5-6 hours (elimination half-life).

Information Not Available

Jaundice and liver dysfunction (reversible); GI disturbances. IV: Venospasm, thrombophloebitis and haemolysis; hypocalcaemia. SC/IM: Tissue necrosis. Topical: Rashes and irritation.

Information Not Available

Hepatic disease; monitor liver function. Neonates; pregnancy, lactation.

Synergistic action with antistaphylococcal penicillin. Antagonism with ciprofloxacin.

Food Interactions
Delays absorption for oral preparations.

Oral
Susceptible infections
Adult: 500 mg tid. May increase to 1 g tid in fulminating infections.
Child: <1 year: About 15 mg/kg; 1-5 years: 250 mg; 5-12 years: 500 mg. Doses to be taken tid.

Intravenous
Susceptible infections
Adult: >50 kg: 500 mg tid; may increase to 1 g tid in fulminating infections. <50 kg: 6-7 mg/kg tid. To be given by slow IV infusion over at least 2 hours; should be given via a large vein with good blood flow.
Child: 20 mg/kg daily in 3 divided doses. To be given by slow IV infusion over at least 2 hours; should be given via a large vein with good blood flow.

Ophthalmic
Conjunctivitis
Adult: As 1% eye drops: Instill 1 drop into the affected eye every 12 hours for 7 days.
Child: ≥2 years: As 1% eye drops: Instill 1 drop into the affected eye every 12 hours for 7 days.

Topical/Cutaneous
Skin infections
Adult: As a 2% ointment/cream/gel: Apply onto affected area 3-4 times daily until there is improvement. If gauze dressing is used, then frequency of application may be reduced to 1-2 times daily.
Child: As a 2% ointment/cream/gel: Apply onto affected area 3-4 times daily until there is improvement. If gauze dressing is used, then frequency of application may be reduced to 1-2 times daily.

Reconstitution
Each 500 mg dose is given as a buffered solution (pH 7.4-7.6) diluted to 500 ml with sodium chloride or other suitable IV solution.

Incompatibility
Incompatible with amino acid solutions or whole blood. Admixture incompatibility: Carbenicillin, kanamycin, gentamicin, calcium solutions.

Should be taken with food

Caution when used during pregnancy

Caution when used during lactation

Information Not Available

Information Not Available

Hypersensitivity.

Intravenous
Store below 25°C.

Ophthalmic
Store between 2-25°C. Discard 1 mth after opening.

Oral
Store below 25°C.

Topical/Cutaneous
Store below 25°C.

Information Not Available