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Fusidic Acid information from DrugsUpdate  

See Available Brands of Fusidic Acid in India

P - Caution when used during pregnancy
L - Caution when used during lactation
FI - Food *

Fusidic acid is a bacteriostatic antibiotic that is often used topically in creams and eyedrops, but may also be given systemically as tablets or injections. The global problem of advancing antimicrobial resistance has led to a renewed interest in its use recently.

Pharmacodynamics

Pharmacokinetics

Fusidic acid disrupts translocation of peptide subunits and elongating the peptide chain of susceptible bacteria, thus inhibiting protein synthesis.

Absorption
Well-absorbed from the GI tract (oral); mean plasma concentrations of 30 mcg/ml after 2-4 hours (500-mg dose). More rapid absorption in children than in adults.

Distribution

Widely distributed into tissues and body fluids including bone, pus and synovial fluid; crosses the placenta and enters breast milk. Protein-binding: 95%.

Metabolism
Hepatic; converted to multiple metabolites.

Excretion

Bile (mainly as metabolites), faeces (2% as unchanged drug), urine; 5-6 hours (elimination half-life).

Fusidic Acid Indications / Fusidic Acid Uses

Information Not Available

Fusidic Acid Adverse Reactions / Fusidic Acid Side Effects

Jaundice and liver dysfunction (reversible); GI disturbances. IV: Venospasm, thrombophloebitis and haemolysis; hypocalcaemia. SC/IM: Tissue necrosis. Topical: Rashes and irritation.

Precautions

Information Not Available

Special Precautions

Hepatic disease; monitor liver function. Neonates; pregnancy, lactation.

Other Drug Interactions

Synergistic action with antistaphylococcal penicillin. Antagonism with ciprofloxacin.

Other Interactions

Food Interactions
Delays absorption for oral preparations.

Dosage

Oral
Susceptible infections
Adult: 500 mg tid. May increase to 1 g tid in fulminating infections.
Child: <1 year: About 15 mg/kg; 1-5 years: 250 mg; 5-12 years: 500 mg. Doses to be taken tid.

Intravenous

Susceptible infections
Adult: >50 kg: 500 mg tid; may increase to 1 g tid in fulminating infections. <50 kg: 6-7 mg/kg tid. To be given by slow IV infusion over at least 2 hours; should be given via a large vein with good blood flow.
Child: 20 mg/kg daily in 3 divided doses. To be given by slow IV infusion over at least 2 hours; should be given via a large vein with good blood flow.

Ophthalmic
Conjunctivitis
Adult: As 1% eye drops: Instill 1 drop into the affected eye every 12 hours for 7 days.
Child: ≥2 years: As 1% eye drops: Instill 1 drop into the affected eye every 12 hours for 7 days.

Topical/Cutaneous
Skin infections
Adult: As a 2% ointment/cream/gel: Apply onto affected area 3-4 times daily until there is improvement. If gauze dressing is used, then frequency of application may be reduced to 1-2 times daily.
Child: As a 2% ointment/cream/gel: Apply onto affected area 3-4 times daily until there is improvement. If gauze dressing is used, then frequency of application may be reduced to 1-2 times daily.

Reconstitution
Each 500 mg dose is given as a buffered solution (pH 7.4-7.6) diluted to 500 ml with sodium chloride or other suitable IV solution.

Incompatibility
Incompatible with amino acid solutions or whole blood. Admixture incompatibility: Carbenicillin, kanamycin, gentamicin, calcium solutions.

Food(before/after)

Should be taken with food

List of Contraindications

Fusidic Acid and Pregnancy

Caution when used during pregnancy

Fusidic Acid and Lactation

Caution when used during lactation

Fusidic Acid and Children

Information Not Available

Fusidic Acid and Geriatic

Information Not Available

Fusidic Acid and Other Contraindications

Hypersensitivity.

Storage

Intravenous
Store below 25°C.

Ophthalmic

Store between 2-25°C. Discard 1 mth after opening.

Oral
Store below 25°C.

Topical/Cutaneous
Store below 25°C.

Lab interference

Intravenous
Store below 25°C.

Ophthalmic

Store between 2-25°C. Discard 1 mth after opening.

Oral
Store below 25°C.

Topical/Cutaneous
Store below 25°C.

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