Fusidic Acid information from DrugsUpdate
L - Caution when used during lactation
FI - Food *
Fusidic acid is a bacteriostatic antibiotic that is often used topically in creams and eyedrops, but may also be given systemically as tablets or injections. The global problem of advancing antimicrobial resistance has led to a renewed interest in its use recently.
Fusidic acid disrupts translocation of peptide subunits and elongating the peptide chain of susceptible bacteria, thus inhibiting protein synthesis.
Well-absorbed from the GI tract (oral); mean plasma concentrations of 30 mcg/ml after 2-4 hours (500-mg dose). More rapid absorption in children than in adults.
Widely distributed into tissues and body fluids including bone, pus and synovial fluid; crosses the placenta and enters breast milk. Protein-binding: 95%.
Hepatic; converted to multiple metabolites.
Bile (mainly as metabolites), faeces (2% as unchanged drug), urine; 5-6 hours (elimination half-life).
Jaundice and liver dysfunction (reversible); GI disturbances. IV: Venospasm, thrombophloebitis and haemolysis; hypocalcaemia. SC/IM: Tissue necrosis. Topical: Rashes and irritation.
Hepatic disease; monitor liver function. Neonates; pregnancy, lactation.
Synergistic action with antistaphylococcal penicillin. Antagonism with ciprofloxacin.
Delays absorption for oral preparations.
Adult: 500 mg tid. May increase to 1 g tid in fulminating infections.
Child: <1 year: About 15 mg/kg; 1-5 years: 250 mg; 5-12 years: 500 mg. Doses to be taken tid.
Adult: >50 kg: 500 mg tid; may increase to 1 g tid in fulminating infections. <50 kg: 6-7 mg/kg tid. To be given by slow IV infusion over at least 2 hours; should be given via a large vein with good blood flow.
Child: 20 mg/kg daily in 3 divided doses. To be given by slow IV infusion over at least 2 hours; should be given via a large vein with good blood flow.
Adult: As 1% eye drops: Instill 1 drop into the affected eye every 12 hours for 7 days.
Child: ≥2 years: As 1% eye drops: Instill 1 drop into the affected eye every 12 hours for 7 days.
Adult: As a 2% ointment/cream/gel: Apply onto affected area 3-4 times daily until there is improvement. If gauze dressing is used, then frequency of application may be reduced to 1-2 times daily.
Child: As a 2% ointment/cream/gel: Apply onto affected area 3-4 times daily until there is improvement. If gauze dressing is used, then frequency of application may be reduced to 1-2 times daily.
Each 500 mg dose is given as a buffered solution (pH 7.4-7.6) diluted to 500 ml with sodium chloride or other suitable IV solution.
Incompatible with amino acid solutions or whole blood. Admixture incompatibility: Carbenicillin, kanamycin, gentamicin, calcium solutions.
Should be taken with food
List of Contraindications
Caution when used during pregnancy
Caution when used during lactation
Store below 25°C.
Store between 2-25°C. Discard 1 mth after opening.
Store below 25°C.
Store below 25°C.
Available brands of Fusidic Acid
- Bactirest (Centaur (Shashvatam))
- Bactirest-M (Centaur (Shashvatam))
- Dicfu (Nidus)
- Dicfu-C (Nidus)
- Fucidin (Ranbaxy (Consumer HC))
- Fucin (Pure Health)
- Fucin-B (Ind- Swift)
- Fucinex (Zuventus (Zuvista))
- Fucithalmic (Win Medicare)
- Fudec (Daksh)
- Fudec-B (Daksh)
- Fudec-M (Daksh)
- Fudic (H & H)
- Fudic-BNF (H & H)
- Fusa (Saga Lab)
- Fusibact (East West)
- Fusibact-B (East West)
- Fusid (Psycorem)
- Fusiderm (Indi Pharma )
- Fusigen (Geno)
- Fusiray (Amray)
- Fusital (Talent)
- Fusiwal (Wallace (Rivella))
- Fusiwal-B (Wallace (Rivella))
- Fuson (Agio)
- Fuson-B (Agio)
- Fuson-H (Agio)
- Fuster (Cutigen)
- Futop (CFL)
- Futop CRM (Cosme HC)
- Futop OINT (Cosme HC)
- Futop-B (CFL)
- Halostrol-F (East West)
- Mecloma-F (Esma)
- Noboyle (Neiss)
- Propyderm-NF (H & H)
- Samadic (Esma)
- Siofin (Alb. David)
- Sofinox (Apex (Skinnova))
- Stafoban (Micro Gratia)
- Vivadic (Biochemix(Vivia))
- Vivadic-B (Biochemix(Vivia))
Fusidic Acid brands in India