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Fluvoxamine information from DrugsUpdate  

See Available Brands of Fluvoxamine in India

P - Caution when used during pregnancy
L - Contraindicated in lactation

Fluvoxamine (Luvox) is an antidepressant which functions as a selective serotonin reuptake inhibitor and is predominantly used to treat obsessive–compulsive disorder.

Pharmacodynamics

Pharmacokinetics

Fluvoxamine, derived from aralkylketone, inhibits the re-uptake of serotonin in brain neurons.

Absorption
Readily absorbed from the GI tract (oral).

Distribution
Protein-binding: 80%.

Metabolism

Extensively hepatic by oxidative demethylation and deamination to inactive metabolites.

Excretion
Urine; 15 hours (elimination half-life).

Fluvoxamine Indications / Fluvoxamine Uses

Information Not Available

Fluvoxamine Adverse Reactions / Fluvoxamine Side Effects

Headache, asthenia, tremor, palpitations, nausea, diarrhoea, constipation, anorexia, vomiting, flatulence, somnolence, insomnia, dry mouth, nervousness, dizziness, tremor, anxiety, agitation, decreased libido, depression, CNS stimulation, dyspnoea, yawn, sweating, abnormal ejaculation, urinary frequency, anorgasmia, urinary retention.

Precautions

Information Not Available

Special Precautions

History of mania or seizures; liver dysfunction; presence of depressive symptoms; smokers. Treatment with MAOI should only be started at least 2 wk after stopping fluvoxamine treatment. Increased risk of suicidal ideation and behaviour when used in children, adolescents and young adults <24 yr. Pregnancy, elderly; operating hazardous machinery; withdraw gradually. Monitor prothrombin time in patients who are taking oral anticoagulants concurrently.

Other Drug Interactions

Co-admin with fluvoxamine may increase carbamazepine toxicity and serum levels of theophylline. Lithium enhances the serotonergic effects of fluvoxamine. Anticoagulants may require dosage adjustments. Diltiazem with fluvoxamine may lead to bradycardia. Avoid alcohol.

Potentially Fatal: Fluvoxamine should not be used in combination with MAOIs, or within 14 days of discontinuing treatment with MAOIs.

Other Interactions

Information Not Available

Dosage

Oral
Depression
Adult: Initially, 50-100 mg daily, may increase gradually up to 300 mg daily, if necessary. Doses >150 mg should be given in 2 or 3 divided doses.

Oral
Obsessive compulsive disorder
Adult: 50 mg once daily; may increase by 50 mg every 4-7 days. Daily doses >100 mg should be given in 2 divided doses. As modified-release preparation: Initial: 100 mg once daily. Max: 300 mg daily.
Child: ≥8 yr: 25 mg once daily, may increase by 25 mg every 4-7 days. Doses >50 mg should be given in 2 divided doses. Reassess if no improvement after 10 weeks of treatment. Max: 200 mg daily.

Oral
Social anxiety disorder
Adult: As modified-release preparation: Initial: 100 mg once daily. Max: 300 mg daily.

Food(before/after)

May be taken with or without food

List of Contraindications

Fluvoxamine and Pregnancy

Caution when used during pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Fluvoxamine and Lactation

Contraindicated in lactation

Fluvoxamine and Children

Information Not Available

Fluvoxamine and Geriatic

Information Not Available

Fluvoxamine and Other Contraindications

Hypersensitivity. Not to be used with thioridazine, terfenadine, astemizole, cisapride, pimozide, aloestron, tizanidine. Lactation.

Storage

Oral
Store at 15-30°C.

Lab interference

Oral
Store at 15-30°C.

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