Flurbiprofen information from DrugsUpdate
L - Contraindicated in lactation
Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs) used to treat the inflammation and pain of arthritis. It is known by the following tradenames: Ansaid, marketed by Pfizer, and Froben, by Abbott. Flurbiprofen is also used as an active ingredient in some kinds of throat lozenges.
The single enantiomer of racemate flurbiprofen, tarenflurbil (R-flurbiprofen), is currently in clinical trials for the treatment of metastatic prostate cancer.
Flurbiprofen inhibits prostaglandin synthesis by decreasing the activity of cyclooxygenase resulting in reduced prostaglandin levels. It is also a potent inhibitor of platelet aggregation.
Readily absorbed from the GIT (oral); peak plasma concentrations after 1-2 hours.
Small amounts enter breast milk. Protein-binding: 99%
Hepatic via hydroxylation and conjugation.
Urine (as metabolites); 3-6 hours (elimination half-life).
Fluid retention, oedema; allergic nephritis, allergic reactions; GI upsets; dizziness, tinnitus, blurring of vision; local irritation, transient burning and stinging (ophthalmic).
Potentially Fatal: Peptic ulceration, haemorrhage and perforation.
NSAIDs may cause an increased risk of serious CV thrombotic events, MI, and stroke, which can be fatal. This risk may increase with length of therapy. Patients with CV disease or risk factors for CV disease may be at greater risk. NSAIDs cause an increased risk of serious GI adverse reactions, including bleeding, ulceration, inflammation, and perforation of the stomach or intestines, which can be fatal. These reactions can occur any time during use and without warning symptoms. Elderly patients are at greater risk of serious GI reactions.
Carefully monitor patients who may be adversely affected by alterations in platelet function (eg, patients with coagulation disorders or receiving anticoagulant therapy). Check CBC and chemistry profile periodically. Follow chronically treated patients for signs and symptoms of GI tract ulceration and bleeding. Monitor LFTs, Hct, and Hgb periodically during long-term therapy. Monitor renal function and patient status carefully in patients with renal function impairment. Perform eye examination if patient experiences visual disturbances.
Hypertension; impaired renal function
Increases serum concentrations of digoxin; may enhance effects of anticoagulants.
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: 150-200 mg daily in divided doses, increased to 300 mg daily in acute or severe conditions if necessary.
Adult: Initially, 100 mg followed by 50-100 mg every 4-6 hours. Max: 300 mg/day.
Adult: 1 lozenge (8.75 mg) every 3-6 hours. Max: 5 lozenges/day. Max treatment duration: 3 days.
Child: <12 yr: Not recommended.
Prophylaxis of miosis during ocular surgery
Adult: As sodium: Instill 1 drop of a 0.03% solution into the eye every 30 minutes starting 2 hours before and ending not < 30 minutes before the surgery.
Postoperative ocular inflammation
Adult: Instill 1 drop of a 0.03% solution into the eye 4 times daily for 1-3 weeks starting at 24 hours after surgery.
Should be taken with food
List of Contraindications
Contraindicated in pregnancy.
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters). in
3rd trimester or near delivery.
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Contraindicated in lactation
Safety and efficacy not established
Use with caution
Peptic ulcer, GI haemorrhage, asthma, bronchospasm, rhinitis, angioedema, hypersensitivity; aspirin intolerance; pregnancy (3rd trimester); lactation.
Store at 15-25°C.
Store at 15-25°C.