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Flavoxate information from DrugsUpdate  

See Available Brands of Flavoxate in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Flavoxate is an anticholinergic with antimuscarinic effects. Its muscle relaxant properties may be due to a direct action on the smooth muscle rather than by antagonizing muscarinic receptors.

Pharmacodynamics

Pharmacokinetics

Flavoxate is a tertiary amine that acts as a smooth muscle relaxant; it also has antimuscarinic effects. It exhibits local anaesthetic, analgesic and spasmolytic effects.

Onset
55 minutes.

Absorption
Readily absorbed from the GI tract after oral admin.

Metabolism
Rapidly metabolised.

Excretion
About 50-60% of a dose is excreted in the urine as methyl flavone carboxylic acid.

Flavoxate Indications / Flavoxate Uses

Information Not Available

Flavoxate Adverse Reactions / Flavoxate Side Effects

Increased intraocular pressure; difficulty in ocular accommodation; blurred vision; dry mouth and throat; GI disturbances; nervousness; vertigo; headache; fatigue; confusion; hypersensitivity reactions; dysuria; tachycardia; palpitation; hyperpyrexia; eosinophilia; leukopenia, abdominal pain, constipation and difficulty in concentrating.

Precautions

Information Not Available

Special Precautions

May affect ability to drive or operate machinery. May worsen hyperthyroidism, coronary artery disease, congestive heart failure, prostatic hypertrophy, arrhythmias, tachycardia. Pregnancy; lactation; elderly; autonomic neuropathy; hiatus hernia with reflux esophagitis, hepatic and renal impairment.

Other Drug Interactions

Amantadine, some antihistamines, phenothiazine antipsychotics, tricyclic antidepressants, MAOIs; parasympathomimetics. May decrease gastric motility thus decreasing absorption of certain drugs. May antagonise the GI effects of cisapride, domperidone, metoclopramide.

Other Interactions

Information Not Available

Dosage

Oral
Urinary incontinence, urgency and frequency, Bladder spasms due to catheterisation, Dysuria
Adult: Usual dose: 200 mg tid.

Food(before/after)

Should be taken on an empty stomach. (May be taken w/ meals to reduce GI discomfort.)

List of Contraindications

Flavoxate and Pregnancy

Caution when used during pregnancy.

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Flavoxate and Lactation

Caution when used during lactation

Flavoxate and Children

Safety and efficacy in children younger than 12 years of age not established.

Flavoxate and Geriatic

Information Not Available

Flavoxate and Other Contraindications

Pyloric or duodenal obstruction; obstructive intestinal lesions or ileus; achalasia; GI haemorhrage or obstructive uropathies of the lower urinary tract; myasthenia gravis; severe ulcerative colitis; toxic megacolon; glaucoma; children <12.

Storage

Oral
Store at 15-30°C.

Lab interference

Oral
Store at 15-30°C.

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