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Bacampicillin information from DrugsUpdate  

See Available Brands of Bacampicillin in India

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Bacampicillin (INN) is a penicillin antibiotic. It is a prodrug of ampicillin with improved oral bioavailability. It is sold under the brand names Spectrobid (Pfizer) and Penglobe (AstraZeneca).

Pharmacodynamics

Pharmacokinetics

Bacampicillin has the antimicrobial action of ampicillin in vivo. It needs to be hydrolysed to ampicillin since it possesses no intrinsic activity.


Absorption Rapidly and absorbed in the GI tract.


Metabolism Hydrolysed in intestinal walls and plasma to ampicillin


Excretion About 75% of a dose is excreted in the urine within 8 hr as ampicillin

Bacampicillin Indications / Bacampicillin Uses

Information Not Available

Bacampicillin Adverse Reactions / Bacampicillin Side Effects

Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis. Nausea; vomiting; pseudomembranous colitis.

Precautions

Information Not Available

Special Precautions

Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitisation may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route. Discontinue in case of skin rash.

Other Drug Interactions

Probenecid prolongs T1/2 of bacampicillin. Bacteriostatic drugs e.g. chloramphenicol, tetracyclines; other antibacterials; anticoagulants.

Other Interactions

Information Not Available

Dosage

Oral Urinary tract infections Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.


Oral Gastroenteritis Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.


Oral Listeriosis Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.


Oral Biliary tract infections Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.


Oral Endocarditis Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.


Oral Meningitis Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.


Oral Otitis media Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.


Oral Peritonitis Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.


Oral Pneumonia Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.


Oral Septicaemia Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.


Oral Bronchitis Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.


Oral Perinatal streptococcal infections Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.


Oral Typhoid and paratyphoid fever Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.


Oral Uncomplicated gonorrhoea Adult: 1.6 g with 1 g probenecid as a single dose.

Food(before/after)

May be taken with or without food (May be taken w/ meals to reduce GI discomfort)

List of Contraindications

Bacampicillin and Pregnancy

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Bacampicillin and Lactation

Information Not Available

Bacampicillin and Children

Information Not Available

Bacampicillin and Geriatic

Information Not Available

Bacampicillin and Other Contraindications

Infectious mononucleosis, lymphatic leukemia, HIV infection; hypersensitivity to penicillins

Storage

Information Not Available

Lab interference

Information Not Available

Bacampicillin brands in India:

Penglobe

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