Ergometrine information from DrugsUpdate
L - Caution when used during lactation
Ergometrine (other names include ergonovine and d-lysergic acid beta-propanolamide), is an ergoline (and lysergamide) derivative, and one of the primary ergot and morning glory alkaloids . It is chemically similar to LSD, ergine, and lysergic acid.
Ergometrine causes contraction of the uterine muscle. At low doses, there is an increase in frequency and amplitude of contractions while at higher doses, the basal tone of the uterus is increased. Ergometrine also causes vasoconstriction of peripheral and cerebral vessels.
5-15 min (oral); 2-7 min (IM).
Rapid absorption from the GI tract (oral).
Nausea, vomiting, abdominal pain, diarrhoea; headache, dizziness; tinnitus; chest pain, palpitation, bradycardia, transient hypertension and other cardiac arrhythmias; dyspnoea, sometimes rashes, shock.
Potentially Fatal: MI, pulmonary oedema.
Breech and abnormal foetal presentation; hypertension; chronic anaemia; hepatic, renal, respiratory or cardiac impairment; toxemia; lactation; hypocalcaemia. Monitor BP, pulse and uterine response.
Halothane causes relaxation of uterine muscle and may interfere with ergometrine action. Enhanced uterotonic effect with prostaglandins and oxytocin. Concurrent admin with CYP3A4 inhibitors may lead to vasospasm, cerebral ischaemia and/or ischaemia of extremities.
Potentially Fatal: Enhanced vasoconstrictive effects with sympathomimetics and other vasoconstrictors
Postpartum and post-abortion bleeding
Adult: 0.2-0.4 mg 2-4 times daily until danger of uterine atony and haemorrhage has passed (usually 48 hours). Max duration: 1 week postpartum.
Excessive uterine bleeding
Adult: 200 mcg via IV inj over at least 1 minute. May follow with oral doses of 200-400 mcg 2-4 times daily until the danger of atony or haemorrhage has passed (usually 48 hours).
Active management of the 3rd stage of labour
Adult: 500 mcg given with 5 units of oxytocin after delivery of the anterior shoulder of the infant or immediately after delivery.
Treatment and prevention of postpartum haemorrhage
Adult: 200 mcg, may repeat in severe bleeding every 2-4 hours as needed.
List of Contraindications
Contraindicated in pregnancy.
Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.
Caution when used during lactation
Pregnancy, 1st and 2nd stage of labour, patients with preeclampsia, eclampsia or threatened spontaneous abortion; porphyria.
Refrigerate at 2-8°C
Store below 25°C