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Quinupristin + Dalfopristin information from DrugsUpdate  

See Available Brands of Quinupristin + Dalfopristin in India

Quinupristin + Dalfopristin are indicated for the treatment of complicated skin and skin structure infection caused by methicillin-susceptible Staphylococcus aureus or Streptococcus pyogenes.

Pharmacodynamics

Quinupristin + Dalfopristin inhibit the bacterial ribosome in the susceptible micro organisms. Dalfopristin and Quinupristin inhibit early phase of protein synthesis and late phase of protein synthesis, respectively. Quinupristin + Dalfopristin exerts bactericidal property against methicillin-resistant and methicillin-susceptible staphylococci.

Pharmacokinetics

No information available

Quinupristin + Dalfopristin Indications / Quinupristin + Dalfopristin Uses

No information available

Quinupristin + Dalfopristin Adverse Reactions / Quinupristin + Dalfopristin Side Effects

Quinupristin + Dalfopristin may phlebitis, abdominal pain, allergic reactions, fever, infections, gout, peripheral edema, myasthenia, arthralgia, urticaria, constipation, sweating, GI upset, constipation, pleural effusion, dyspnoea, sweating, urticaria, vaginitis, hematuria, injection-site reactions, pain, rashes and pruritus.

Precautions

Caution should be exercised while administering Quinupristin + Dalfopristin to avoid thrombophlebitis, myalgia, arthralgia, super-infections and hyperbilirubinemia.

Special Precautions

No information available

Other Drug Interactions

Quinupristin + Dalfopristin may interact with digoxin, cytochrome P4503A4 inhibitors, gentamicin, amoxicillin, tetracyclines, quinolones, beta-lactams, anti-histaminic drugs, benzodiazepines, HMG-CoA reductase inhibitors, calcium-channel blockers, anti-neoplastic drugs, protease inhibitors, benzodiazepines and Clostridium difficile associated diarrhea (CDAD)

Other Interactions

No information available

Dosage

Quinupristin + Dalfopristin should be administered as an intravenous infusion in 5% dextrose in water over one hour. The recommended dose of Quinupristin + Dalfopristin is 7.5 mg/kg, q12 h for seven days.

Food(before/after)

No information available

List of Contraindications

Quinupristin + Dalfopristin and Pregnancy

USFDA pregnancy category B. Quinupristin + Dalfopristin may not cause harm to an unborn foetus. Before Quinupristin + Dalfopristin treatment, the patient should discuss with the physician, if they are planning for a pregnancy.

Quinupristin + Dalfopristin and Lactation

It is unclear whether the drug could pass through the breast milk to a breast feeding baby. Consult your physician before taking Quinupristin + Dalfopristin, if you are nursing mother.

Quinupristin + Dalfopristin and Children

Quinupristin + Dalfopristin should not be given to children younger than 16 years of age.

Quinupristin + Dalfopristin and Geriatic

No information available

Quinupristin + Dalfopristin and Other Contraindications

No information available

Storage

No information available

Lab interference

No information available

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