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Perphenazine information from DrugsUpdate  

See Available Brands of Perphenazine in India

Perphenazine is a phenothiazine anti-psychotic drug is indicated for the treatment of psychosis.

Pharmacodynamics

The piperazine side chain containing drug is able to block postsynaptic mesolimbic dopaminergic receptors in the brain. The alpha-adrenergic blocking effect of Perphenazine inhibits the biosynthesis and release of hypothalamic and hypophyseal hormones.

Pharmacokinetics

After oral administration, Perphenazine is well-absorbed with bioavailability of 60-80%. The Cmax of the drug is 1-3 hours. After administration, the drug is widely distributed in the blood and cross placental barrier. Perphenazine is rapidly metabolized in the liver. The terminal plasma half-life of Perphenazine is about 9-12 hours. The drug is mostly eliminated via the urine as drug metabolites.

Perphenazine Indications / Perphenazine Uses

No information available

Perphenazine Adverse Reactions / Perphenazine Side Effects

Perphenazine can cause cardiac arrest, blood dyscrasia, neuroleptic malignant syndrome, blood pressure changes, arrhythmia, orthostatic hypotension, insomnia, dizziness, galactorrhoea, gynecomastia, diaphoresis, nasal congestion, vision changes, obstructive jaundice, difficulty in urination, glucose imbalance and photosensitivity.

Precautions

Perphenazine is contraindicated in patients with blood dyscrasia, CNS depression, bone marrow depression, coma and sub-cortical brain marrow. Caution should be exercised while prescribing Perphenazine to patients with traumatic head injury, hypovolemia, CVD, narrow-angle glaucoma, urinary retention, BPH, xerostomia, paralytic ileus, decreased GI motility, dehydration, myasthenia gravis, Parkinson’s disease, prolactin-dependent tumors and respiratory disorders.

Special Precautions

No information available

Other Drug Interactions

Perphenazine may interact with amphetamine, acetylcholine inhibitors, benztropine, TCA, hypotensive drugs, trazodone, aluminium salts, biperiden, guanethidine, quinine, ritonavir, propranolol, sulfadoxine, lithium, disopyramide, polypeptide antibiotics, propranolol, miconazole and guanadrel.

Other Interactions

Do not consume alcohol while taking Perphenazine

Dosage

For Schizophrenia (Adults):
Start with an initial oral dose of 4mg, thrice daily. The maximum dose should not exceed over 24 mg/day.
 
For Mania (Adults):
Start with an initial oral dose of 4mg, thrice daily. The maximum dose should not exceed over 24 mg/day.
 
Psychoses (Adults):
Start with an initial oral dose of 4mg, thrice daily. The maximum dose should not exceed over 24 mg/day.
 
For treatment of nausea or vomiting (Adults):
Consider administration of 4mg, thrice daily. The dosage can be increased up to 8mg, thrice daily.
 
Acute anxiety (Adults):
Start with an initial oral dose of 4mg, thrice daily. The maximum dose should not exceed over 24 mg/day.
 
For treatment of severe agitation and violent behaviours (Adults):
Start with an initial oral dose of 4mg, thrice daily. The maximum dose should not exceed over 24 mg/day.

Food(before/after)

Should be taken with food

List of Contraindications

Perphenazine and Pregnancy

USFDA pregnancy category C. May be or may not be harmful to an unborn baby. Consult your doctor if you are in gestation or planning to have a baby during Perphenazine treatment.

Perphenazine and Lactation

Nursing mothers should consult a physician before taking Perphenazine.

Perphenazine and Children

Perphenazine should not be used in children unless prescribed by a pediatrician

Perphenazine and Geriatic

No information available

Perphenazine and Other Contraindications

No information available

Storage

No information available

Lab interference

No information available

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