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Molgramostim information from DrugsUpdate  

See Available Brands of Molgramostim in India

Molgramostim, an immunostimulant that belong to colony-stimulating factor, is prescribed for the treatment of Ganciclovir-induced neutropenia, chemotherapy-associated neutropenia and bone marrow transplantation associated complications.

Pharmacodynamics

The granulocyte-macrophage colony-stimulating factor (GM-CSF) involves in the growth, differentiation and functions of macrophages, eosinophils and granulocytes. The drug facilitates the differentiation of granulocytes and macrophage and promotes cellular physiology.

Pharmacokinetics

No information available

Molgramostim Indications / Molgramostim Uses

No information available

Molgramostim Adverse Reactions / Molgramostim Side Effects

Molgramostim can cause anaphylactic reactions, cardiac arrhythmia, pleural and peri-cardial effusion, fever, chills, bone and musculoskeletal pain, abdominal pain, formation of auto-antibodies, anorexia, stomatitis, asthenia, pruritus, peripheral edema and flushing.

Precautions

Molgramostim is contraindicated in patients with pre-existing breathing disorders, fluid retention, heart failure, pre-cancerous or hematological malignancies and pulmonary infiltrates.

Monitor CBC regularly while taking Molgramostim.

Special Precautions

No information available

Other Drug Interactions

Molgramostim may interact seriously with bleomycin.

Other Interactions

No information available

Dosage

For treatment of chemotherapy-induced neutropenia (Adults):
As a SC injection, administer 5-10 mcg/kg as an initial dose. The dosage should be continued for 7-10 days. The maximum dosage should not exceed 10 mcg/kg/day.
For treatment of Ganciclovir-induced neutropenia

(Adults):
Consider 5 mcg/kg/day as SC injection. After the 5th dose, the dosage can be adjusted in accordance to PMN counts. The maximum daily dosage should not exceed 10 mcg/kg.
 
For prevention of BMT complications (Adults):
Consider administration of 10 mcg/kg/day as an IV infusion. The treatment should be continued over 4-6 hours on the first day of BMT. The treatment should be continued up to 30 days. The maximum daily dose should not exceed 10 mcg/kg.

Food(before/after)

No information available

List of Contraindications

Molgramostim and Pregnancy

USFDA Pregnancy Category is unknown. Caution should be exercised before prescribing Molgramostim to pregnant women.

Molgramostim and Lactation

No adequate clinical studies to demonstrate the safety of Molgramostim in lactating mothers.

Molgramostim and Children

Molgramostim should not be used in children unless prescribed by a pediatrician

Molgramostim and Geriatic

No information available

Molgramostim and Other Contraindications

No information available

Storage

Store at 2-8°C. Do not freeze. Protect away from direct light.

Lab interference

Store at 2-8°C. Do not freeze. Protect away from direct light.

Molgramostim brands in India:

Macrogen

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