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Alpha-Lipoic Acid information from DrugsUpdate  

See Available Brands of Alpha-Lipoic Acid in India

Alpha-lipoic acid is a naturally occurring fatty acid that can be found in many foods such as yeast, spinach, broccoli, potatoes, and organ meats such as liver or kidney.

Alpha-lipoic acid has been used as a nutritional supplement and antioxidant.

Alpha-lipoic acid is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Pharmacodynamics

Pharmacokinetics

Information Not Available

Alpha-Lipoic Acid Indications / Alpha-Lipoic Acid Uses

Information Not Available

Alpha-Lipoic Acid Adverse Reactions / Alpha-Lipoic Acid Side Effects

Information Not Available

Precautions

Overdosage
Symptoms may include anorexia, lassitude, nausea and vomiting, constipation or diarrhoea, polyuria, nocturia, sweating, headache, thirst, somnolence and vertigo and hypercalcaemia. Management: Stop admin of alfacalcidol. Treatment is symptomatic and supportive. Ensure patient is well hydrated by i.v. infusion of saline (force diuresis). Monitor electrolytes, calcium levels, renal function, ECG (especially in patients on digitalis). Consider treatment with glucocorticosteroids, loop diuretics, bisphosphonates, calcitonin and haemodialysis with low calcium content.

Special Precautions

Pregnancy, lactation, renal impairment, infants, elderly. Monitor serum levels of calcium in patients with renal failure. Caution in hypercalciuria esp in those with history of renal calculi. Avoid in patients with hypersensitivity to inj. containing propylene glycol.

Other Drug Interactions

Thiazides may increase the risk of hypercalcaemia. Some antiepileptics e.g. carbamazepine, phenobarbital, phenytoin and primidone may increase vitamin D requirements. Rifampicin, isoniazid and corticosteroids may reduce the efficacy of vitamin D.

Other Interactions

Information Not Available

Dosage

Oral
Hypocalcaemia, Renal osteodystrophy, Hypoparathyroidism, Rickets or osteomalacia, Hypophosphataemia
Adult: Initially, 1 mcg daily. Maintenance: 0.25-1 mcg daily.
Child: Premature infants and neonates: 0.05-0.1 mcg/kg daily; <20 kg: 0.05 mcg/kg daily.
Elderly: 0.5 mcg daily.

Food(before/after)

Should be taken with food

List of Contraindications

Alpha-Lipoic Acid and Pregnancy

Information Not Available

Alpha-Lipoic Acid and Lactation

Information Not Available

Alpha-Lipoic Acid and Children

Information Not Available

Alpha-Lipoic Acid and Geriatic

Information Not Available

Alpha-Lipoic Acid and Other Contraindications

Information Not Available

Storage

Oral
Capsule: Store below 25°C. Liquid: Refrigerate at 2-8°C.

Lab interference

Oral
Capsule: Store below 25°C. Liquid: Refrigerate at 2-8°C.

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