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Magnesium Valproate information from DrugsUpdate  

See Available Brands of Magnesium Valproate in India

Magnesium Valproate, an anticonvulsant drug, is prescribed for the management of seizures in any individuals over two years of age. Magnesium Valproate can prevent abnormal mood swings in bipolar disorder patients and for the treatment of simple and complex absence seizures.

Pharmacodynamics

The magnesium salts of Valproic acid inhibit the enzymatic action of inhibitory neurotransmitters such as GABA at higher centers. Magnesium exerts sedating and anti-neoplastic activity by inhibiting the histone deacetylase associated with cellular apoptosis.

Pharmacokinetics

No information available

Magnesium Valproate Indications / Magnesium Valproate Uses

No information available

Magnesium Valproate Adverse Reactions / Magnesium Valproate Side Effects

Magnesium Valproate can cause pancreatitis, elevated LFTs, hyperammonaemia, anorexia, nausea, hallucinations, bulimia, ataxia, decreased platelet counts, fatal hepatotoxicity, blood dyscrasias, somnolence, fatigue, tremors, dizziness, nystagmus and diarrhoea.

Precautions

Magnesium Valproate is contraindicated in patients with renal disorders, hepatic diseases and cardiac disorders.
Magnesium Valproate can cause dizziness. Do not drive vehicles or operate heavy machineries that need mental alertness.

Special Precautions

No information available

Other Drug Interactions

Magnesium Valproate can interact with hormonal OCPs including patches, rifampin, other anti-convulsant drugs, anti-histamine drugs, aspirin, sedatives, anxiolytics, narcotic analgesics, psychiatric drugs and muscle relaxants.

Other Interactions

Do not consume alcohol while taking Magnesium Valproate

Dosage

The treatment is personalized. The dosage and duration of Magnesium Valproate depends on the patient’s medical condition and severity.

Food(before/after)

Magnesium Valproate can be taken before or after food intake

List of Contraindications

Magnesium Valproate and Pregnancy

USFDA pregnancy category D. Magnesium Valproate can harm the unborn fetus. Perform pregnancy tests before using Magnesium Valproate. Use effective contraceptive mode to prevent unintended pregnancies while taking Magnesium Valproate.

Magnesium Valproate and Lactation

Nursing mothers should consult the healthcare provider before Magnesium Valproate treatment.

Magnesium Valproate and Children

Magnesium Valproate is contraindicated in children less than two years of age

Magnesium Valproate and Geriatic

No information available

Magnesium Valproate and Other Contraindications

No information available

Storage

Store at 15-30oC.

Lab interference

Store at 15-30oC.

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