Ilaprazole, a novel proton pump inhibitor (PPI), is used for the treatment of gastroesophageal reflux disorders (GERD), dyspepsia and peptic ulcers.
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After oral administration, the drug is rapidly absorbed. The drug is extensively metabolized to Ilaprazole sulfone via the CYP450 enzymes. The drug is primarily excreted in the urine as drug metabolites and unchanged drug to some extent.
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Ilaprazole can cause mild to moderate GI discomfort with anorexia, fatigue, weight loss, nausea or vomiting and indigestion.
Ilaprazole should not be prescribed to individuals who are allergic to other PPIs.
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Ilaprazole may interact with Clarithromycin, midazolam, ketoconazole and amoxicillin
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The recommended adult dosage of Ilaprazole is 5-20 mg/day
Ilaprazole should be taken at least 30 minutes before food intake
USFDA Pregnancy category of Ilaprazole is unknown. Do not use Ilaprazole, if you are in gestation
Nursing mothers should consult a physician before taking Ilaprazole
Ilaprazole should not be given to children unless prescribed by a pediatrician
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