logo image

Zotepine information from DrugsUpdate  

See Available Brands of Zotepine in India

Zotepine, an atypical anti-psychotic drug, is prescribed for the treatment of schizophrenia in adults and geriatrics.

Pharmacodynamics

Zotepine is an antagonist at central Dopamine (D1 and D2) receptors. Zotepine binds with adrenergic receptors, serotonin and histamine (H1) receptors. Zotepine selectively inhibits noradrenaline reuptake.

Pharmacokinetics

Zotepine is rapidly absorbed in GIT. After absorption, Cmax can be achieved within 2-3 hours. The plasma protein binding capability is about 97%. Zotepine is well distributed in the body fluids including breast milk. The drug is metabolized by hepatic first-pass metabolism. Zotepine is metabolized by CYP3A4 and CYP1A2. Zotepine is excreted via the urine and feces as inactive drug metabolites. The terminal plasma half-life of Zotepine is about 14 hours.

Zotepine Indications / Zotepine Uses

No information available

Zotepine Adverse Reactions / Zotepine Side Effects

Zotepine can cause neuroleptic malignant syndrome, elevated liver function tests, headache, vision changes, extrapyramidal effects, behavioural changes, insomnia, GI disturbances, blood dyscrasias, photophobia and unexplained weight gain.

Precautions

Zotepine is contraindicated in patients with pre-existing QT prolongation, renal stones, acute gouty attacks, paralytic ileus, CNS depression, CAD with or without angina pectoris, pheochromocytoma, prostate hyperplasia, neuroblastoma, Parkinson’s disease, closed-angle glaucoma, behavioural disorders and convulsion.

Monitor ECG, LFTs and electrolyte profile regularly while taking Zotepine.
Do not withdraw Zotepine abruptly to avoid withdrawal symptoms.

Special Precautions

No information available

Other Drug Interactions

Zotepine may interact with CNS depressants, sedatives, hypnotics, anti-hypertensive drugs, anesthetic drugs and anti-muscarinic drugs.

Other Interactions

Do not consume alcohol while taking Zotepine. Alcohol may cause additive effects.

Dosage

For Schizophrenia (Adults):
Start with an initial oral dose of 25 mg of Zotepine thrice daily. The dosage can be increased with four days apart. The maximum daily dose should not exceed 100 mg thrice daily.
 
For Schizophrenia (Geriatrics):
Start with an initial oral dose of 25 mg twice daily. The dosage can be gradually increased based on clinical response. The maximum daily dose should not exceed 75 mg, twice daily.

Food(before/after)

No information available

List of Contraindications

Zotepine and Pregnancy

USFDA pregnancy category B. Zotepine may not cause harm to an unborn foetus. Before Zotepine treatment, the patient should discuss with the physician, if they are planning for a pregnancy. 
Zotepine and Lactation

Zotepine can pass through the breast milk and harm a nursing baby. Consult your physician before taking Zotepine, if you are nursing mother.

Zotepine and Lactation

No information available

Zotepine and Children

No information available

Zotepine and Geriatic

No information available

Zotepine and Other Contraindications

No information available

Storage

No information available

Lab interference

No information available

© 2011-2020 DrugsUpdate.com. Disclaimer | Site Map

Feedback
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.